Long Non-Coding RNAs in Sjögren’s Disease
Abstract
:1. Introduction
2. Skewed X Chromosomal Inactivation
3. Long, Non-Coding RNAs Link Genetic Risk to Cell-Type Specific Function
4. Long, Non-Coding RNAs as Biomarkers
5. Immunomodulatory Properties of Long, Non-Coding RNAs
6. Conclusions
lcnRNA | NONCODE Gene ID | Origin | Method | No. of Patients (Discovery Cohort) | Validation Method | No. of Patients (Validation Cohort) | Up- or Downregulation (SjD versus Control) | Reference |
---|---|---|---|---|---|---|---|---|
lnc-DC | n.a. | blood plasma | qPCR | 149 pSjD, 50 SLE, 50 RA, 109 HC | n.v. | up | [60] | |
LINC01871 | NONHSAG026917.2 | whole blood | RNA-seq | 50 SjD § (27 Ro+, 23 Ro−), 27 HC | qPCR | 22 SjD (14 Ro+, 8 Ro−), 24 HC | up in SjD (Ro+ and Ro−) | [61] |
NRIR | NONHSAT068918.2 | up in SjD Ro+ | ||||||
OAS123-AS1 | n.a. | |||||||
MX1-AS1 | n.a. | |||||||
GBP5-AS1 | n.a. | |||||||
TPTEP1-202 | n.a. | PBMCs | RNA-seq | 5 pSjD, 5 HC | qPCR | 16 pSjD, 6 HC | down | [72] |
LINC00426 | NONHSAG013150.2 | up | ||||||
CYTOR | NONHSAG077527.2 | |||||||
NRIR | NONHSAG026902.2 | |||||||
BISPR | NONHSAG025088.3 | |||||||
LINC00657 | NONHSAG031696.3 | PBMCs | microarray analysis | 8 pSjD, 8 HC | qPCR | n.a. | down | [70] |
LINC00511 | NONHSAG022655.3 | up up | ||||||
CTD-2020K17.1 | n.a. | |||||||
GABPB1-AS1 | NONHSAG016861.3 | PBMCs | RNA-seq | 4 pSjD, 4 HC | qPCR | 30 pSjD, 15 HC | up | [71] |
PSMA3-AS1 | NONHSAG015097.3 | |||||||
TMEVPG1 (NeST, IFN-γ-AS1) | NONHSAG011599.2 | CD4+ T cells | qPCR | 20 pSjD, 10 HC | n.v. | up | [76] | |
NEAT1 | NONHSAG008670.3 | CD4+ T cells | qPCR | 20 pSjD, 10 HC | n.v. | up | [74] | |
PVT1 | n.a. | CD4+ T cells | qPCR | 25 SjD, 25 HC | n.v. | up | [73] | |
LINC00487 | NONHSAG026900.2 | B-cells | microarray analysis | 6 pSjD, 6 HC | qPCR | 14 pSjD, 12 HC | up | [78] |
CTA-250D10.23 | n.a. | parotid gland | microarray analysis | 19 pSjD, 20 HC, 20 nSS | microarray analysis (labial SG) * | up | [68] | |
KIAA0125 | n.a. | |||||||
LOC100505812 | n.a. | |||||||
BZRAP1-AS1 | n.a. | |||||||
LINC01215 | NONHSAT194282.1 | |||||||
PSMB8-AS1 | NONHSAT108940.2 | |||||||
ITGB2-AS1 | NONHSAT082896.2 | |||||||
LOC100505549 | n.a. | |||||||
LOC101929272 | n.a. | |||||||
ENST00000420219.1 | n.a. | labial SG | microarray analysis | 4 pSjD, 4 C (mucocele excision) | qPCR | 30 pSjD, 16 C (mucocele excision) | up | [67] |
ENST00000455309.1 | NONHSAG028948.3 | |||||||
NR_002712 | n.a. | |||||||
ENST00000546086.1 | NONHSAG011610.3 | |||||||
n340599 | NONHSAG041352.2 | |||||||
TCONS_l2_00014794 | n.a. | |||||||
n336161 | n.a. | |||||||
lnc-UTS2D-1:1 | n.a. |
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Pastva, O.; Klein, K. Long Non-Coding RNAs in Sjögren’s Disease. Int. J. Mol. Sci. 2024, 25, 5162. https://doi.org/10.3390/ijms25105162
Pastva O, Klein K. Long Non-Coding RNAs in Sjögren’s Disease. International Journal of Molecular Sciences. 2024; 25(10):5162. https://doi.org/10.3390/ijms25105162
Chicago/Turabian StylePastva, Ondřej, and Kerstin Klein. 2024. "Long Non-Coding RNAs in Sjögren’s Disease" International Journal of Molecular Sciences 25, no. 10: 5162. https://doi.org/10.3390/ijms25105162