Role of Epigenetics in Degenerative and Inflammatory Rheumatic Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 428
Special Issue Editor
2. Center of Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
3. President of OMTh, Levico Terme, Italy
Interests: osteoarthritis; rheumatic diseases; microRNA; chondrocyte cultures; psoriatic arthritis; rheumatoid arthritis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The term ‘epigenetics’ was first proposed by Conrad Waddington in 1942, but the interest in this field has increased rapidly over the last few decades.
Currently, epigenetic refers to heritable structural and biochemical alterations of the chromatin without affecting DNA sequence. These processes include DNA methylation and demethylation, histone and non-coding RNA (ncRNA) modifications.
Growing evidence suggest the implication of epigenetic mechanisms in several pathological conditions, such as cancer, obesity, metabolic syndrome, diabetes, cardiovascular and rheumatological disorders. Current data suggest that aberrant epigenetic modifications play a key role in the pathophysiology of different degenerative and inflammatory musculoskeletal diseases. Furthermore, the investigations in this topic may help to identify new potential biomarkers and new possible target therapy for some rheumatological disorders.
This Special Issue aims to highlight recent advance, current challenges and future perspectives in the field of epigenetic alterations in the development, diagnosis and therapeutic management of degenerative and inflammatory musculoskeletal conditions.
For this topic, original research articles, review articles, meta-analyses and systematic reviews are welcome.
Dr. Antonella Fioravanti
Guest Editor
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Keywords
- DNA methylation
- histone modification
- non-coding RNAs
- long noncoding RNAs
- microRNA
- transfer RNA
- ribosomal RNA
- small interfering RNA
- circular RNA
- osteoarthritis
- rheumatoid arthritis
- psoriatic arthritis
- inflammatory rheumatic diseases
- biomarkers
