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Review

Chondrotoxicity of Intra-Articular Injection Treatment: A Scoping Review

1
Department of Neurosciences, Institute of Human Anatomy, University of Padua, 35121 Padua, Italy
2
Physical and Rehabilitation Medicine, Department of Clinical Sciences and Translational Medicine, Tor Vergata University, 00133 Rome, Italy
3
Department of Medicine—DIMED, School of Radiology, Radiology Institute, University of Padua, 35121 Padua, Italy
4
Internal Medicine, S. Pietro Fatebenefratelli Hospital, 00189 Rome, Italy
5
Rheumatology, S. Pietro Fatebenefratelli Hospital, 00189 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(13), 7010; https://doi.org/10.3390/ijms25137010
Submission received: 7 May 2024 / Revised: 10 June 2024 / Accepted: 24 June 2024 / Published: 26 June 2024
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Abstract

The purpose of this scoping review was to identify possible chondrotoxic effects caused by drugs usually used for intra-articular injections. PubMed, Scopus, Web of Science and Cochrane were searched. Inclusion criteria required randomized controlled trials written in English that evaluate the toxic effect that damages the cartilage. The literature search resulted in 185 unique articles. 133 full-text articles were screened for inclusion, of which 65 were included. Corticosteroids, with the exception of triamcinolone, along with local anaesthetics, potentially excluding ropivacaine and liposomal bupivacaine, and nonsteroidal anti-inflammatory drugs, exhibited insufficient safety profiles to warrant casual use in clinical settings. Hyaluronic acid, on the other hand, appears to demonstrate safety while also mitigating risks associated with concurrent compounds, thereby facilitating therapeutic combinations. Additionally, there remains a paucity of data regarding platelet-rich plasma, necessitating further evaluation of its potential efficacy and safety. Overall, it seems that results are significantly influenced by the dosage and frequency of injections administered, observed in both human and animal studies.
Keywords: chondrotoxicity; intra-articular injection; corticosteroids; local anaesthetic; nonsteroidal anti-inflammatory drugs; hyaluronic acids; platelet-rich plasma (PRP) chondrotoxicity; intra-articular injection; corticosteroids; local anaesthetic; nonsteroidal anti-inflammatory drugs; hyaluronic acids; platelet-rich plasma (PRP)

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MDPI and ACS Style

Pirri, C.; Sorbino, A.; Manocchio, N.; Pirri, N.; Devito, A.; Foti, C.; Migliore, A. Chondrotoxicity of Intra-Articular Injection Treatment: A Scoping Review. Int. J. Mol. Sci. 2024, 25, 7010. https://doi.org/10.3390/ijms25137010

AMA Style

Pirri C, Sorbino A, Manocchio N, Pirri N, Devito A, Foti C, Migliore A. Chondrotoxicity of Intra-Articular Injection Treatment: A Scoping Review. International Journal of Molecular Sciences. 2024; 25(13):7010. https://doi.org/10.3390/ijms25137010

Chicago/Turabian Style

Pirri, Carmelo, Andrea Sorbino, Nicola Manocchio, Nina Pirri, Antonio Devito, Calogero Foti, and Alberto Migliore. 2024. "Chondrotoxicity of Intra-Articular Injection Treatment: A Scoping Review" International Journal of Molecular Sciences 25, no. 13: 7010. https://doi.org/10.3390/ijms25137010

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