Interactions with DNA Models of the Oxaliplatin Analog (cis-1,3-DACH)PtCl2 †
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis and Characterization of [PtCl2(cis-1,3-DACH)]
2.2. Reaction with G Nucleotides
2.2.1. 9-EthylGuanine (9-EtG)
2.2.2. Guanosine (Guo)
2.2.3. 5′GMP
2.2.4. 3′GMP
2.2.5. Variable Temperature NMR Experiments on (cis-1,3-DACH)Pt(5′GMP)2 and (cis-1,3-DACH)Pt(3′GMP)2
2.2.6. Deoxyguanosil(3′-5′)deoxyguanosine (d(GpG))
3. Materials and Methods
3.1. Synthesis of the Complexes
3.1.1. [PtCl2(cis-1,3-DACH)]
3.1.2. (cis-1,3-DACH)PtG2 Adducts (G = 9-EthylGuanine, Guanosine, 3′-GMP, and 5′-GMP)
3.1.3. (cis-1,3-DACH)Pt(d(GpG)) Adduct (d(GpG) = Deoxyguanosil(3′-5′)deoxyguanosine)
3.2. Solutions for Circular Dichroism (CD) Spectroscopy
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Adduct | G sx/dx | cis-1,3-DACH | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
H8 | CH2a | CH3b | H1′ | H2′ | H3′ | H4′ | H5′ | H5″ | H1/3 | H2ax | H2eq | H5ax | H5eq | H4/6 | |
9-EtG | 8.21 | 4.10 | 1.38 | - | - | - | - | - | - | 2.99 | 1.87 | 2.10 | 4.49 | 1.95 | 1.81 |
Guanosine | 8.44 | - | - | 5.89 | 4.60 | 4.33 | 4.23 | 3.84 | 3.77 | 2.97 | 1.80 | 2.08 | 4.46 | 1.92 | 1.74 |
5′GMP | 8.52 | - | - | 5.92 | 4.67 | 4.47 | 4.34 | 4.13 | 4.13 | 2.97 | 1.84 | 2.07 | 4.44 | 1.91 | 1.73 |
8.50 | - | - | 5.90 | 4.62 | 4.41 | 4.34 | 4.13 | 4.13 | |||||||
3′GMP | 8.49 | - | - | 5.94 | 4.64 | 4.37 | 3.93 | 3.84 | 3.84 | 2.98 | 1.83 | 2.08 | 4.51 | 1.94 | 1.75 |
8.47 | - | - | 5.94 | 4.67 | 4.37 | 3.91 | 3.86 | 3.86 |
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Barbanente, A.; Papadia, P.; Di Cosola, A.M.; Pacifico, C.; Natile, G.; Hoeschele, J.D.; Margiotta, N. Interactions with DNA Models of the Oxaliplatin Analog (cis-1,3-DACH)PtCl2 . Int. J. Mol. Sci. 2024, 25, 7392. https://doi.org/10.3390/ijms25137392
Barbanente A, Papadia P, Di Cosola AM, Pacifico C, Natile G, Hoeschele JD, Margiotta N. Interactions with DNA Models of the Oxaliplatin Analog (cis-1,3-DACH)PtCl2 . International Journal of Molecular Sciences. 2024; 25(13):7392. https://doi.org/10.3390/ijms25137392
Chicago/Turabian StyleBarbanente, Alessandra, Paride Papadia, Anna Maria Di Cosola, Concetta Pacifico, Giovanni Natile, James D. Hoeschele, and Nicola Margiotta. 2024. "Interactions with DNA Models of the Oxaliplatin Analog (cis-1,3-DACH)PtCl2 " International Journal of Molecular Sciences 25, no. 13: 7392. https://doi.org/10.3390/ijms25137392