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Volume 25
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Review

Navigating the Modern Landscape of Sepsis: Advances in Diagnosis and Treatment

by
Jin Ho Jang
1,2,
Eunjeong Choi
1,2,
Taehwa Kim
1,2,
Hye Ju Yeo
1,2,
Doosoo Jeon
1,2,
Yun Seong Kim
1,2 and
Woo Hyun Cho
1,2,*
1
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Transplantation Research Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea
2
Department of Internal Medicine, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(13), 7396; https://doi.org/10.3390/ijms25137396
Submission received: 31 May 2024 / Revised: 27 June 2024 / Accepted: 3 July 2024 / Published: 5 July 2024
(This article belongs to the Special Issue Diagnostic and Therapeutic Advances in the Management of Sepsis and Septic Shock—2nd Edition)
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Abstract

Sepsis poses a significant threat to human health due to its high morbidity and mortality rates worldwide. Traditional diagnostic methods for identifying sepsis or its causative organisms are time-consuming and contribute to a high mortality rate. Biomarkers have been developed to overcome these limitations and are currently used for sepsis diagnosis, prognosis prediction, and treatment response assessment. Over the past few decades, more than 250 biomarkers have been identified, a few of which have been used in clinical decision-making. Consistent with the limitations of diagnosing sepsis, there is currently no specific treatment for sepsis. Currently, the general treatment for sepsis is conservative and includes timely antibiotic use and hemodynamic support. When planning sepsis-specific treatment, it is important to select the most suitable patient, considering the heterogeneous nature of sepsis. This comprehensive review summarizes current and evolving biomarkers and therapeutic approaches for sepsis.
Keywords: sepsis; septic shock; biomarker; diagnosis; treatment; immunomodulation; novel sepsis; septic shock; biomarker; diagnosis; treatment; immunomodulation; novel

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MDPI and ACS Style

Jang, J.H.; Choi, E.; Kim, T.; Yeo, H.J.; Jeon, D.; Kim, Y.S.; Cho, W.H. Navigating the Modern Landscape of Sepsis: Advances in Diagnosis and Treatment. Int. J. Mol. Sci. 2024, 25, 7396. https://doi.org/10.3390/ijms25137396

AMA Style

Jang JH, Choi E, Kim T, Yeo HJ, Jeon D, Kim YS, Cho WH. Navigating the Modern Landscape of Sepsis: Advances in Diagnosis and Treatment. International Journal of Molecular Sciences. 2024; 25(13):7396. https://doi.org/10.3390/ijms25137396

Chicago/Turabian Style

Jang, Jin Ho, Eunjeong Choi, Taehwa Kim, Hye Ju Yeo, Doosoo Jeon, Yun Seong Kim, and Woo Hyun Cho. 2024. "Navigating the Modern Landscape of Sepsis: Advances in Diagnosis and Treatment" International Journal of Molecular Sciences 25, no. 13: 7396. https://doi.org/10.3390/ijms25137396

APA Style

Jang, J. H., Choi, E., Kim, T., Yeo, H. J., Jeon, D., Kim, Y. S., & Cho, W. H. (2024). Navigating the Modern Landscape of Sepsis: Advances in Diagnosis and Treatment. International Journal of Molecular Sciences, 25(13), 7396. https://doi.org/10.3390/ijms25137396

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