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Article

Antioxidant Activity and the Therapeutic Effect of Sinomenine Hydrochloride-Loaded Liposomes-in-Hydrogel on Atopic Dermatitis

by
Xue Chen
,
Yang Wu
,
Ruoyang Jia
,
Yuqing Fang
,
Keang Cao
,
Xinying Yang
,
Xiaobo Qu
and
Hongmei Xia
*
College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
*
Author to whom correspondence should be addressed.
These authors should be co-first authors due to their contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(14), 7676; https://doi.org/10.3390/ijms25147676
Submission received: 5 June 2024 / Revised: 7 July 2024 / Accepted: 10 July 2024 / Published: 12 July 2024
(This article belongs to the Special Issue New Perspectives of Colloids for Biological Applications)

Abstract

Sinomenine hydrochloride is an excellent drug with anti-inflammatory, antioxidant, immune-regulatory, and other functions. Atopic dermatitis is an inherited allergic inflammation that causes itchiness, redness, and swelling in the affected area, which can have a significant impact on the life of the patient. There are many therapeutic methods for atopic dermatitis, and sinomenine with immunomodulatory activity might be effective in the treatment of atopic dermatitis. In this study, the atopic dermatitis model was established in experimental mice, and physical experiments were carried out on the mice. In the experiment, sinomenine hydrochloride liposomes-in-hydrogel as a new preparation was selected for delivery. In this case, liposomes were dispersed in the colloidal hydrogel on a mesoscopic scale and could provide specific transfer properties. The results showed that the sinomenine hydrochloride-loaded liposomes-in-hydrogel system could effectively inhibit atopic dermatitis.
Keywords: sinomenine; liposomes-in-hydrogel; colloidal hydrogel; anti-inflammatory; atopic dermatitis sinomenine; liposomes-in-hydrogel; colloidal hydrogel; anti-inflammatory; atopic dermatitis

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MDPI and ACS Style

Chen, X.; Wu, Y.; Jia, R.; Fang, Y.; Cao, K.; Yang, X.; Qu, X.; Xia, H. Antioxidant Activity and the Therapeutic Effect of Sinomenine Hydrochloride-Loaded Liposomes-in-Hydrogel on Atopic Dermatitis. Int. J. Mol. Sci. 2024, 25, 7676. https://doi.org/10.3390/ijms25147676

AMA Style

Chen X, Wu Y, Jia R, Fang Y, Cao K, Yang X, Qu X, Xia H. Antioxidant Activity and the Therapeutic Effect of Sinomenine Hydrochloride-Loaded Liposomes-in-Hydrogel on Atopic Dermatitis. International Journal of Molecular Sciences. 2024; 25(14):7676. https://doi.org/10.3390/ijms25147676

Chicago/Turabian Style

Chen, Xue, Yang Wu, Ruoyang Jia, Yuqing Fang, Keang Cao, Xinying Yang, Xiaobo Qu, and Hongmei Xia. 2024. "Antioxidant Activity and the Therapeutic Effect of Sinomenine Hydrochloride-Loaded Liposomes-in-Hydrogel on Atopic Dermatitis" International Journal of Molecular Sciences 25, no. 14: 7676. https://doi.org/10.3390/ijms25147676

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