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Open AccessReview
Applications of Modified Mesenchymal Stem Cells as Targeted Systems against Tumor Cells
by
Elsa N. Garza Treviño
Elsa N. Garza Treviño 1,
Adriana G. Quiroz Reyes
Adriana G. Quiroz Reyes 1,
Paulina Delgado Gonzalez
Paulina Delgado Gonzalez 1,
Juan Antonio Rojas Murillo
Juan Antonio Rojas Murillo 1,
Jose Francisco Islas
Jose Francisco Islas 1,
Santiago Saavedra Alonso
Santiago Saavedra Alonso 2 and
Carlos A. Gonzalez Villarreal
Carlos A. Gonzalez Villarreal 2,*
1
Laboratorio de Terapia Celular, Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo León, Av. Dr. José Eleuterio González 235, Monterrey 64460, Nuevo León, Mexico
2
Departamento de Ciencias Básicas, Vicerrectoría de Ciencias de la Salud, Universidad de Monterrey, Ignacio Morones Prieto 4500, Jesus M. Garza, San Pedro Garza García 66238, Nuevo León, Mexico
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(14), 7791; https://doi.org/10.3390/ijms25147791 (registering DOI)
Submission received: 30 May 2024
/
Revised: 22 June 2024
/
Accepted: 26 June 2024
/
Published: 16 July 2024
Abstract
Combined gene and cell therapy are promising strategies for cancer treatment. Given the complexity of cancer, several approaches are actively studied to fight this disease. Using mesenchymal stem cells (MSCs) has demonstrated dual antitumor and protumor effects as they exert massive immune/regulatory effects on the tissue microenvironment. MSCs have been widely investigated to exploit their antitumor target delivery system. They can be genetically modified to overexpress genes and selectively or more efficiently eliminate tumor cells. Current approaches tend to produce more effective and safer therapies using MSCs or derivatives; however, the effect achieved by engineered MSCs in solid tumors is still limited and depends on several factors such as the cell source, transgene, and tumor target. This review describes the progress of gene and cell therapy focused on MSCs as a cornerstone against solid tumors, addressing the different MSC-engineering methods that have been approached over decades of research. Furthermore, we summarize the main objectives of engineered MSCs against the most common cancers and discuss the challenges, limitations, risks, and advantages of targeted treatments combined with conventional ones.
Share and Cite
MDPI and ACS Style
Garza Treviño, E.N.; Quiroz Reyes, A.G.; Delgado Gonzalez, P.; Rojas Murillo, J.A.; Islas, J.F.; Saavedra Alonso, S.; Gonzalez Villarreal, C.A.
Applications of Modified Mesenchymal Stem Cells as Targeted Systems against Tumor Cells. Int. J. Mol. Sci. 2024, 25, 7791.
https://doi.org/10.3390/ijms25147791
AMA Style
Garza Treviño EN, Quiroz Reyes AG, Delgado Gonzalez P, Rojas Murillo JA, Islas JF, Saavedra Alonso S, Gonzalez Villarreal CA.
Applications of Modified Mesenchymal Stem Cells as Targeted Systems against Tumor Cells. International Journal of Molecular Sciences. 2024; 25(14):7791.
https://doi.org/10.3390/ijms25147791
Chicago/Turabian Style
Garza Treviño, Elsa N., Adriana G. Quiroz Reyes, Paulina Delgado Gonzalez, Juan Antonio Rojas Murillo, Jose Francisco Islas, Santiago Saavedra Alonso, and Carlos A. Gonzalez Villarreal.
2024. "Applications of Modified Mesenchymal Stem Cells as Targeted Systems against Tumor Cells" International Journal of Molecular Sciences 25, no. 14: 7791.
https://doi.org/10.3390/ijms25147791
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