The Interplay between Endogenous and Foodborne Pro-Oxidants and Antioxidants in Shaping Redox Homeostasis
Abstract
:1. Oxidative Stress—Definition and Evolution of the Concept
2. ROS and Their Endogenous Production
3. Exposome-Derived (Exogenous) ROS
3.1. Diet-Induced Oxidative Stress
3.2. Alcohol Consumption
3.3. Environmental Pollutants Entering the Food Chain
4. ROS as Inducers of Oxidative Damage to Biomolecules
4.1. Oxidation of Nucleic Acids
4.2. Lipid Peroxidation
4.3. Oxidative Modifications of Proteins
5. Antioxidants and the Maintenance of Redox Homeostasis
6. Efficacy of Antioxidants
7. Underestimated Relevance of Redox Chemistry
8. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Triggers of ROS Production | |
---|---|
Endogenous | Exogenous |
Cytosol Purine catabolism Auto-oxidation of low-molecular-weight compounds Endoplasmic reticulum Xenobiotic metabolism Unsaturated fatty acid biosynthesis Protein folding Thiol oxidase reactions Mitochondria Electron transport chain: complex I (sites IF, IQ); complex III (site IIIQo) Monoamine oxidase α-Ketoglutarate dehydrogenase Pyruvate dehydrogenase Glycerol 3-phosphate dehydrogenase The electron transfer flavoprotein: Q oxidoreductase p66shc Peroxisomes Fatty acid α- and β-oxidation Ether-phospholipid biosynthesis Glyoxylate metabolism Amino acid catabolism Polyamine oxidation Oxidative part of the pentose phosphate pathway Plasma membrane Arachidonic acid oxidation Phagocytic and non-phagocytic oxidative burst | Physical stressors UV radiation Ionizing radiation Chemical stressors Air pollutants Tobacco smoke Heavy metals Drugs (e.g., paracetamol, doxorubicin) Micro- and nanoplastics Diet-derived Oxidized oils Thermally processed meat Pesticides Alcohol Mental stressors Negative life changes Catastrophic events Daily hassles Chronic emotional stressors |
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Jakubek, P.; Parchem, K.; Wieckowski, M.R.; Bartoszek, A. The Interplay between Endogenous and Foodborne Pro-Oxidants and Antioxidants in Shaping Redox Homeostasis. Int. J. Mol. Sci. 2024, 25, 7827. https://doi.org/10.3390/ijms25147827
Jakubek P, Parchem K, Wieckowski MR, Bartoszek A. The Interplay between Endogenous and Foodborne Pro-Oxidants and Antioxidants in Shaping Redox Homeostasis. International Journal of Molecular Sciences. 2024; 25(14):7827. https://doi.org/10.3390/ijms25147827
Chicago/Turabian StyleJakubek, Patrycja, Karol Parchem, Mariusz R. Wieckowski, and Agnieszka Bartoszek. 2024. "The Interplay between Endogenous and Foodborne Pro-Oxidants and Antioxidants in Shaping Redox Homeostasis" International Journal of Molecular Sciences 25, no. 14: 7827. https://doi.org/10.3390/ijms25147827