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Open AccessReview
Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option?
by
Shania Bieri
Shania Bieri 1,
Burkhard Möller
Burkhard Möller 2
and
Jennifer Amsler
Jennifer Amsler 2,3,*
1
Faculty of Medicine, University of Bern, 3012 Bern, Switzerland
2
Department of Rheumatology and Immunology, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
3
Department for BioMedical Research DBMR, University of Bern, 3008 Bern, Switzerland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(15), 8212; https://doi.org/10.3390/ijms25158212 (registering DOI)
Submission received: 30 April 2024
/
Revised: 12 July 2024
/
Accepted: 22 July 2024
/
Published: 27 July 2024
Abstract
Ferroptosis is a form of iron-dependent regulated cell death caused by the accumulation of lipid peroxides. In this review, we summarize research on the impact of ferroptosis on disease models and isolated cells in various types of arthritis. While most studies have focused on rheumatoid arthritis (RA) and osteoarthritis (OA), there is limited research on spondylarthritis and crystal arthropathies. The effects of inducing or inhibiting ferroptosis on the disease strongly depend on the studied cell type. In the search for new therapeutic targets, inhibiting ferroptosis in chondrocytes might have promising effects for any type of arthritis. On the other hand, ferroptosis induction may also lead to a desired decrease of synovial fibroblasts in RA. Thus, ferroptosis research must consider the cell-type-specific effects on arthritis. Further investigation is needed to clarify these complexities.
Share and Cite
MDPI and ACS Style
Bieri, S.; Möller, B.; Amsler, J.
Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option? Int. J. Mol. Sci. 2024, 25, 8212.
https://doi.org/10.3390/ijms25158212
AMA Style
Bieri S, Möller B, Amsler J.
Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option? International Journal of Molecular Sciences. 2024; 25(15):8212.
https://doi.org/10.3390/ijms25158212
Chicago/Turabian Style
Bieri, Shania, Burkhard Möller, and Jennifer Amsler.
2024. "Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option?" International Journal of Molecular Sciences 25, no. 15: 8212.
https://doi.org/10.3390/ijms25158212
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