Next Article in Journal
Neurological Disorders Induced by Drug Use: Effects of Adolescent and Embryonic Drug Exposure on Behavioral Neurodevelopment
Next Article in Special Issue
Activity of N-Chlorotaurine against Periodontal Pathogens
Previous Article in Journal
Characterization of GPX Gene Family in Pepper (Capsicum annuum L.) under Abiotic Stress and ABA Treatment
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

N-Chlorotaurine Solutions as Agents for Infusion Detoxification Therapy: Preclinical Studies

1
Department of Biochemistry and Medical Chemistry, Dnipro State Medical University, 49044 Dnipro, Ukraine
2
Clinical Hospital of Emergency Medical Care of the Dnipro City Council, 65 Volodymyra Antonovycha Str., 49000 Dnipro, Ukraine
3
Department of Physical Chemistry, Ukrainian State University of Chemical Technology, 8 Gagarina Ave., 49005 Dnipro, Ukraine
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(15), 8345; https://doi.org/10.3390/ijms25158345 (registering DOI)
Submission received: 16 June 2024 / Revised: 18 July 2024 / Accepted: 19 July 2024 / Published: 30 July 2024

Abstract

N-chlorotaurine (NCT) is a broad-spectrum antimicrobial agent with outstanding tolerability, effective for topical and inhalation use. This paper presents the results of studies of single and repeated intravenous infusions of NCT to laboratory animals. The studies were conducted on female Wistar Han rats. The effect of NCT infusions on the general condition, behavioral reactions, main biochemical and hematological parameters, hemocoagulation system, cardiovascular system, and on the condition of the internal organs was studied. It was found that NCT infusions do not reveal deviations in the studied parameters that could indicate a toxic effect. The estimated LD50 is more than 80 mg/kg. In a subchronic experiment, a statistically significant decrease in cholesterol (by up to 11%), glucose (by up to 15%) and excess bases (up to four times) in the blood, and an increase in heart rate (by up to 31%) and frequency of defecations (by up to 35%), as well as pronounced antiplatelet effect, were found. In animals with simulated endotoxicosis, a decrease in the cytolysis and oxidative stress markers was observed. Such effects are caused by both chlorine-active compounds and taurine.The results obtained indicate broad prospects for the use of NCT solutions as an infusion detoxifying agent.
Keywords: N-chlorotaurine; active chlorine; N-chloramines; antimicrobial; infusion; detoxification therapy N-chlorotaurine; active chlorine; N-chloramines; antimicrobial; infusion; detoxification therapy

Share and Cite

MDPI and ACS Style

Murashevych, B.; Bilenkyi, G.; Girenko, D.; Bilenkyi, E. N-Chlorotaurine Solutions as Agents for Infusion Detoxification Therapy: Preclinical Studies. Int. J. Mol. Sci. 2024, 25, 8345. https://doi.org/10.3390/ijms25158345

AMA Style

Murashevych B, Bilenkyi G, Girenko D, Bilenkyi E. N-Chlorotaurine Solutions as Agents for Infusion Detoxification Therapy: Preclinical Studies. International Journal of Molecular Sciences. 2024; 25(15):8345. https://doi.org/10.3390/ijms25158345

Chicago/Turabian Style

Murashevych, Bohdan, Gennadii Bilenkyi, Dmitry Girenko, and Emil Bilenkyi. 2024. "N-Chlorotaurine Solutions as Agents for Infusion Detoxification Therapy: Preclinical Studies" International Journal of Molecular Sciences 25, no. 15: 8345. https://doi.org/10.3390/ijms25158345

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Article metric data becomes available approximately 24 hours after publication online.
Back to TopTop