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Open AccessArticle
N-Chlorotaurine Solutions as Agents for Infusion Detoxification Therapy: Preclinical Studies
by
Bohdan Murashevych
Bohdan Murashevych 1,*,
Gennadii Bilenkyi
Gennadii Bilenkyi 2,
Dmitry Girenko
Dmitry Girenko 3 and
Emil Bilenkyi
Emil Bilenkyi 1
1
Department of Biochemistry and Medical Chemistry, Dnipro State Medical University, 49044 Dnipro, Ukraine
2
Clinical Hospital of Emergency Medical Care of the Dnipro City Council, 65 Volodymyra Antonovycha Str., 49000 Dnipro, Ukraine
3
Department of Physical Chemistry, Ukrainian State University of Chemical Technology, 8 Gagarina Ave., 49005 Dnipro, Ukraine
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(15), 8345; https://doi.org/10.3390/ijms25158345 (registering DOI)
Submission received: 16 June 2024
/
Revised: 18 July 2024
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Accepted: 19 July 2024
/
Published: 30 July 2024
Abstract
N-chlorotaurine (NCT) is a broad-spectrum antimicrobial agent with outstanding tolerability, effective for topical and inhalation use. This paper presents the results of studies of single and repeated intravenous infusions of NCT to laboratory animals. The studies were conducted on female Wistar Han rats. The effect of NCT infusions on the general condition, behavioral reactions, main biochemical and hematological parameters, hemocoagulation system, cardiovascular system, and on the condition of the internal organs was studied. It was found that NCT infusions do not reveal deviations in the studied parameters that could indicate a toxic effect. The estimated LD50 is more than 80 mg/kg. In a subchronic experiment, a statistically significant decrease in cholesterol (by up to 11%), glucose (by up to 15%) and excess bases (up to four times) in the blood, and an increase in heart rate (by up to 31%) and frequency of defecations (by up to 35%), as well as pronounced antiplatelet effect, were found. In animals with simulated endotoxicosis, a decrease in the cytolysis and oxidative stress markers was observed. Such effects are caused by both chlorine-active compounds and taurine.The results obtained indicate broad prospects for the use of NCT solutions as an infusion detoxifying agent.
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MDPI and ACS Style
Murashevych, B.; Bilenkyi, G.; Girenko, D.; Bilenkyi, E.
N-Chlorotaurine Solutions as Agents for Infusion Detoxification Therapy: Preclinical Studies. Int. J. Mol. Sci. 2024, 25, 8345.
https://doi.org/10.3390/ijms25158345
AMA Style
Murashevych B, Bilenkyi G, Girenko D, Bilenkyi E.
N-Chlorotaurine Solutions as Agents for Infusion Detoxification Therapy: Preclinical Studies. International Journal of Molecular Sciences. 2024; 25(15):8345.
https://doi.org/10.3390/ijms25158345
Chicago/Turabian Style
Murashevych, Bohdan, Gennadii Bilenkyi, Dmitry Girenko, and Emil Bilenkyi.
2024. "N-Chlorotaurine Solutions as Agents for Infusion Detoxification Therapy: Preclinical Studies" International Journal of Molecular Sciences 25, no. 15: 8345.
https://doi.org/10.3390/ijms25158345
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