Sex-Specific Differences in Kidney Function and Blood Pressure Regulation
Abstract
:1. Introduction
2. Sex and Hypertension
3. Kidney and Blood Pressure
4. Endothelins
5. Tubule Transporters
5.1. Epithelial Sodium Channel (ENaC)
5.2. Sodium–Hydrogen Exchanger 3 (NHE3)
5.3. Aquaporins
6. Renin–Angiotensin–Aldosterone System
7. Sex-Specific Genetic Susceptibilities in Hypertension: Insights from GWAS
8. Sex-Specific Nutraceutical Approaches
9. Conclusions
Funding
Conflicts of Interest
References
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Study | Population | Key Findings |
---|---|---|
Messerli, F.H. et al. [11] | Male and female patients with hypertension | Found that men have higher blood pressure compared to women starting at puberty, with this trend reversing after menopause. |
van Kesteren, P.J.M [12] | M—>F and F→M transexuals | Male-to-female transsexuals exhibit lower ET levels after estrogen supplementation, whereas testosterone treatment in female-to-male transsexuals leads to an increase in ET levels. |
Phillips, G.B. et al. [9] | Men with coronary artery disease | Found an association of hypotestosteronemia with coronary artery disease in men. |
Christakou, C.D. et al. [13] | Women with polycystic ovary syndrome | Discussed the role of androgen excess on metabolic aberrations and cardiovascular risk in women with PCOS. |
Chen, W. et al. [14] | Men and women without hypertension at baseline | Suggested that the endothelial NO synthase gene may contribute to the predisposition of females for hypertension |
Curtis, J.J. et al. [15] | Hypertensive patients undergoing renal transplantation | Found remission of essential hypertension after renal transplantation. |
Zapater P. et al. [16] | Men and women with hypertension | Found that women had lower blood pressure and angiotensin converting enzyme (ACE) activities than men |
Ruggenenti P. et al. [17] | Men and women with hypertension | Found that men exhibit a lower response to ACE inhibitor treatment |
Cho, S.B. et al. [18] | GWAS | Indicated a sex-specific genetic susceptibility to hypertension |
Song, S. et al. [19] | Men and women without hypertension at baseline | Found that a diet rich in grains and legumes is inversely associated with the risk of hypertension in Korean women |
Kang, Y. et al. [20] | Men and women without hypertension at baseline | Found that frequent fried food consumption is associated with hypertension in Korean women |
Animal Model | Sex-Specific Findings | References |
---|---|---|
Spontaneously Hypertensive Rats (SHRs) | Testosterone mediates hypertension via AR; flutamide decreases blood pressure | [21,22,23,24,25] |
Deoxycorticosterone Acetate (DOCA)-Salt Rats | Higher blood pressure elevation in males; Endothelin B (ETB) receptor knockout abolishes blood pressure differences | [26] |
Ren2 Gene-Expressing Rats | Flutamide lowers blood pressure and reduces organ damage | [27] |
Orchidectomized Sprague Dawley Rats | Testosterone increases ENaC expression; castration decreases blood pressure | [28,29] |
Ovariectomized Rats | Salt-independent hypertension in DS rats post-ovariectomy | [30,31] |
Angiotensin II (Ang II)-Infused Mice | Blood pressure increase in females with male kidney; Angiotensing 1 receptor (AT1R) and endothelin 1 (ET-1) mRNA differences | [32] |
High-Fat Diet (HFD)-Induced Hypertension | HFD induces hypertension in males; losartan prevents this; and females resistant due to Ang (1–7) | [33] |
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Stamellou, E.; Sterzer, V.; Alam, J.; Roumeliotis, S.; Liakopoulos, V.; Dounousi, E. Sex-Specific Differences in Kidney Function and Blood Pressure Regulation. Int. J. Mol. Sci. 2024, 25, 8637. https://doi.org/10.3390/ijms25168637
Stamellou E, Sterzer V, Alam J, Roumeliotis S, Liakopoulos V, Dounousi E. Sex-Specific Differences in Kidney Function and Blood Pressure Regulation. International Journal of Molecular Sciences. 2024; 25(16):8637. https://doi.org/10.3390/ijms25168637
Chicago/Turabian StyleStamellou, Eleni, Viktor Sterzer, Jessica Alam, Stefanos Roumeliotis, Vassilios Liakopoulos, and Evangelia Dounousi. 2024. "Sex-Specific Differences in Kidney Function and Blood Pressure Regulation" International Journal of Molecular Sciences 25, no. 16: 8637. https://doi.org/10.3390/ijms25168637