The Key Targets of NO-Mediated Post-Translation Modification (PTM) Highlighting the Dynamic Metabolism of ROS and RNS in Peroxisomes
Abstract
:1. Introduction
2. Production of Oxygen Radicals in Peroxisomes
3. Peroxisomes Serve as Generators of Not Only ROS but Also NOS, Which Function as Signaling Molecules
4. Nitric Oxide-Induced S-Nitrosylation, Tyrosine Nitration, Transnitrosylation, and Denitrosylation Processes
4.1. Catalase
4.2. S-Nitrosation of Catalase
4.3. Tyrosine Nitration and Metabolism of RO
4.4. Monodehydroascorbate Reductase
4.5. SOD Emerges as a Significant Protein Warranting Further Exploration as a Target of PTMs Mediated by NO
5. Conclusions and Future Perspectives
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Peroxisomal Enzyme | Function | Effect on Activity | Effect on Activity | References |
---|---|---|---|---|
Hydroxypyruvate reductase (HPR) | Photorespiration | S-nitrosation/Tyr nitration | Inhibition/Inhibition | [51] |
Glycolate oxidase (GOX) | Photorespiration | S-nitrosation/Tyr nitration | Inhibition/Inhibition | [52] |
Malate dehydrogenase (MDH) | Fatty acid β-oxidation | S-nitrosation/Tyr nitration | Inhibition/Inhibition | [53] |
Catalase (CAT) | H2O2 decomposition | S-nitrosation/Tyr nitration | Inhibition/Inhibition | [54] |
CuZn superoxide dismutase (CSD3) | O2•− dismutation | Tyr nitration | Inhibition/Inhibition | [55] |
Monodehydroascorbate reductase (MDAR) | Ascorbate glutathione cycle | S-nitrosation/Tyr nitration | Inhibition/Inhibition | [56,57] |
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Ergashev, U.; Yu, M.; Luo, L.; Tang, J.; Han, Y. The Key Targets of NO-Mediated Post-Translation Modification (PTM) Highlighting the Dynamic Metabolism of ROS and RNS in Peroxisomes. Int. J. Mol. Sci. 2024, 25, 8873. https://doi.org/10.3390/ijms25168873
Ergashev U, Yu M, Luo L, Tang J, Han Y. The Key Targets of NO-Mediated Post-Translation Modification (PTM) Highlighting the Dynamic Metabolism of ROS and RNS in Peroxisomes. International Journal of Molecular Sciences. 2024; 25(16):8873. https://doi.org/10.3390/ijms25168873
Chicago/Turabian StyleErgashev, Ulugbek, Mei Yu, Long Luo, Jie Tang, and Yi Han. 2024. "The Key Targets of NO-Mediated Post-Translation Modification (PTM) Highlighting the Dynamic Metabolism of ROS and RNS in Peroxisomes" International Journal of Molecular Sciences 25, no. 16: 8873. https://doi.org/10.3390/ijms25168873