Cellular and Molecular Effects of Magnetic Fields
Abstract
:1. Introduction
1.1. Magnetic Field Parameters
1.2. Magnetic Fields and Magnetosensitivity of Biological Systems
1.3. Geomagnetic Fields (GMFs)
2. Biological Properties of Membranes
3. Cell Morphology and Motility
4. Cellular Differentiation and Proliferation
5. Potential Genotoxicity of Magnetic Fields
6. Neurological Effects
7. Potential Therapeutic Applications of Magnetic Fields
7.1. Transcranial Magnetic Stimulation (TMS)
7.2. Magnetic Seizure Therapy (MST)
8. Electromagnetic Sensing and Imaging
8.1. Magnetocardiography
8.2. Magnetoencaphalopathy
8.3. Magnetic Resonance Imaging (MRI) Enhancement
9. Biomedical Applications of Magnetic Fields
9.1. Magnetic Hyperthermia
9.2. Magnetic Targeting
9.3. Regenerative Medicine
10. Interactions with Nanoparticles
11. Conclusions
12. Future Directions and Challenges
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Magnetic Field Parameters | Cell Line | Biological Effects | Ref. |
---|---|---|---|
50 Hz, 1 mT for 1 h | HaCaT keratinocyte | Induced proliferation via mTOR (PI3K/Akt) and ERK signaling pathways | [2] |
60 Hz, 1.5 mT for 144 h | HaCaT keratinocyte | Inhibited cell growth, activated ATM-Chk2-p21 pathway (G1 arrest) | [3] |
60 Hz, 6 mT for 30 min every 24 h for 3 days | IMR90, HeLa | Induced DNA double-strand breaks (DSBs) and apoptosis via p38 activation; increased micronucleus formation and chromosomal aberrations. | [4] |
60 Hz, 7 mT for 10–60 min | IMR90, HeLa | Induced DNA DSBs without apoptosis, activated DNA damage checkpoint without ROS production; increased DNA repair foci formation | [5] |
50 Hz, 1 mT for 24/48/72 h | SH-SY5Y | Significantly increased ROS levels | [6] |
2 ± 0.2 mT; 75 ± 2 Hz for 10 min, 4 times/week | SH-SY5Y | Decreased H2O2-induced ROS | [7] |
30 Hz, 0.8 mT for 1 h | 6B 1 hybridoma | Inhibited proliferation; variable effects at different frequencies | [8] |
60 Hz, 20, and 200 μT for various times up to 30 h | Human fibroblasts | Increased G1 phase length at lower intensities, no effect at higher flux densities | [9] |
50 Hz, 100 μT, 0.6 mT, 24 h, 48 h | K562, DU145 cells | Significantly increased cell proliferation; micronucleus formation observed | [10,11] |
50, 60 Hz, 2, 20, 100, 500 μT, 24 h, 48 h | K562 cells | No effect on cell proliferation | [12] |
(104–105) Tm−1, static | Cancer cells enriched by Fe | Tumor arrest | [13] |
(103–105) Tm−1, static | HeLa cells, other cancerous cells with low membrane tension | Magnetically assisted cell division | [13] |
(102–103) Tm−1, static | PC-3 cells and fibroblasts | Magnetically assisted endocytosis | [14] |
103 Tm−1, static | THP-1 cells | Cell swelling | [15] |
50 Hz, 1 mT for 12 h/day for 3 days | Human lymphocytes | Increased ROS production and DNA fragmentation; increased micronucleus frequency and chromosomal aberrations | [16] |
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Tota, M.; Jonderko, L.; Witek, J.; Novickij, V.; Kulbacka, J. Cellular and Molecular Effects of Magnetic Fields. Int. J. Mol. Sci. 2024, 25, 8973. https://doi.org/10.3390/ijms25168973
Tota M, Jonderko L, Witek J, Novickij V, Kulbacka J. Cellular and Molecular Effects of Magnetic Fields. International Journal of Molecular Sciences. 2024; 25(16):8973. https://doi.org/10.3390/ijms25168973
Chicago/Turabian StyleTota, Maciej, Laura Jonderko, Julia Witek, Vitalij Novickij, and Julita Kulbacka. 2024. "Cellular and Molecular Effects of Magnetic Fields" International Journal of Molecular Sciences 25, no. 16: 8973. https://doi.org/10.3390/ijms25168973