Olfactory Projections to Locomotor Control Centers in the Sea Lamprey
Abstract
:1. Introduction
2. Results
2.1. The medOB Projects to DA Neurons of the PT
2.2. Stimulation of the Olfactomotor Circuitry Induces Neuronal Responses in the PT
2.3. Neural Activity in the PT during Locomotion Induced by the Olfactomotor Circuitry
2.4. Neural Activity in the PT during Spontaneous Locomotion
3. Discussion
3.1. medOB Projections to DA Neurons of the PT
3.2. MOB and LPal Projections to the PT
3.3. Convergence of the Medial and Lateral Olfactomotor Pathways in the PT
3.4. The Role of the PT in Olfactory-Induced Locomotion
3.5. The Role of the PT in Locomotion
4. Materials and Methods
4.1. Animals
4.2. Anatomical Experiments
4.2.1. Isolated Whole Brain Preparation
4.2.2. Tracer Injection
4.2.3. Dopamine, Glutamate, and GABA Immunofluorescence
4.2.4. Fluorescence and Confocal Microscopy
4.2.5. Cleared Brain Whole Mount
4.3. Physiological Experiments
4.3.1. Isolated Forebrain Preparation
4.3.2. Electrical Stimulation
4.3.3. Drug Application
4.3.4. Extracellular Recordings
4.3.5. Whole-Cell Patch Clamp
4.3.6. Calcium Imaging
4.3.7. Intracellular Recordings (Sharp Glass Microelectrodes)
4.3.8. Semi-Intact Preparation
4.3.9. Kinematic Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Beauséjour, P.-A.; Veilleux, J.-C.; Condamine, S.; Zielinski, B.S.; Dubuc, R. Olfactory Projections to Locomotor Control Centers in the Sea Lamprey. Int. J. Mol. Sci. 2024, 25, 9370. https://doi.org/10.3390/ijms25179370
Beauséjour P-A, Veilleux J-C, Condamine S, Zielinski BS, Dubuc R. Olfactory Projections to Locomotor Control Centers in the Sea Lamprey. International Journal of Molecular Sciences. 2024; 25(17):9370. https://doi.org/10.3390/ijms25179370
Chicago/Turabian StyleBeauséjour, Philippe-Antoine, Jean-Christophe Veilleux, Steven Condamine, Barbara S. Zielinski, and Réjean Dubuc. 2024. "Olfactory Projections to Locomotor Control Centers in the Sea Lamprey" International Journal of Molecular Sciences 25, no. 17: 9370. https://doi.org/10.3390/ijms25179370