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Article

Inhibitory Effects of Surface Pre-Reacted Glass Ionomer Filler Eluate on Streptococcus mutans in the Presence of Sucrose

by
Mariko Kametani
1,†,
Tatsuya Akitomo
1,†,
Masakazu Hamada
2,
Momoko Usuda
1,
Ami Kaneki
1,
Masashi Ogawa
1,
Shunya Ikeda
1,
Yuya Ito
1,
Shuma Hamaguchi
1,
Satoru Kusaka
1,
Yuria Asao
1,
Yuko Iwamoto
1,
Chieko Mitsuhata
1,
Yuto Suehiro
3,
Rena Okawa
3,
Kazuhiko Nakano
3 and
Ryota Nomura
1,*
1
Department of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan
2
Department of Oral & Maxillofacial Oncology and Surgery, Osaka University Graduate School of Dentistry, Suita 565-0871, Japan
3
Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Suita 565-0871, Japan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(17), 9541; https://doi.org/10.3390/ijms25179541
Submission received: 24 July 2024 / Revised: 16 August 2024 / Accepted: 27 August 2024 / Published: 2 September 2024
(This article belongs to the Special Issue Dental Health and Disease: From the Molecular and Pathological Perspectives)
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Abstract

The surface pre-reacted glass ionomer (S-PRG) filler is a type of bioactive functional glass that releases six different ions. This study examined the effects of the S-PRG filler eluate on Streptococcus mutans in the presence of sucrose. In a solution containing S. mutans, the concentrations of BO33−, Al3+, Sr2+, and F− were significantly higher in the presence of the S-PRG filler eluate than in its absence (p < 0.001). The concentrations of these ions further increased in the presence of sucrose. Additionally, the S-PRG filler eluate significantly reduced glucan formation by S. mutans (p < 0.001) and significantly increased the pH of the bacterial suspension (p < 0.001). Bioinformatic analyses revealed that the S-PRG filler eluate downregulated genes involved in purine biosynthesis (purC, purF, purL, purM, and purN) and upregulated genes involved in osmotic pressure (opuAa and opuAb). At a low pH (5.0), the S-PRG filler eluate completely inhibited the growth of S. mutans in the presence of sucrose and significantly increased the osmotic pressure of the bacterial suspension compared with the control (p < 0.001). These findings suggest that ions released from the S-PRG filler induce gene expression changes and exert an inhibitory effect on S. mutans in the presence of sucrose.
Keywords: surface pre-reacted glass ionomer (S-PRG) filler; Streptococcus mutans; ions; sucrose; RNA sequence surface pre-reacted glass ionomer (S-PRG) filler; Streptococcus mutans; ions; sucrose; RNA sequence

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MDPI and ACS Style

Kametani, M.; Akitomo, T.; Hamada, M.; Usuda, M.; Kaneki, A.; Ogawa, M.; Ikeda, S.; Ito, Y.; Hamaguchi, S.; Kusaka, S.; et al. Inhibitory Effects of Surface Pre-Reacted Glass Ionomer Filler Eluate on Streptococcus mutans in the Presence of Sucrose. Int. J. Mol. Sci. 2024, 25, 9541. https://doi.org/10.3390/ijms25179541

AMA Style

Kametani M, Akitomo T, Hamada M, Usuda M, Kaneki A, Ogawa M, Ikeda S, Ito Y, Hamaguchi S, Kusaka S, et al. Inhibitory Effects of Surface Pre-Reacted Glass Ionomer Filler Eluate on Streptococcus mutans in the Presence of Sucrose. International Journal of Molecular Sciences. 2024; 25(17):9541. https://doi.org/10.3390/ijms25179541

Chicago/Turabian Style

Kametani, Mariko, Tatsuya Akitomo, Masakazu Hamada, Momoko Usuda, Ami Kaneki, Masashi Ogawa, Shunya Ikeda, Yuya Ito, Shuma Hamaguchi, Satoru Kusaka, and et al. 2024. "Inhibitory Effects of Surface Pre-Reacted Glass Ionomer Filler Eluate on Streptococcus mutans in the Presence of Sucrose" International Journal of Molecular Sciences 25, no. 17: 9541. https://doi.org/10.3390/ijms25179541

APA Style

Kametani, M., Akitomo, T., Hamada, M., Usuda, M., Kaneki, A., Ogawa, M., Ikeda, S., Ito, Y., Hamaguchi, S., Kusaka, S., Asao, Y., Iwamoto, Y., Mitsuhata, C., Suehiro, Y., Okawa, R., Nakano, K., & Nomura, R. (2024). Inhibitory Effects of Surface Pre-Reacted Glass Ionomer Filler Eluate on Streptococcus mutans in the Presence of Sucrose. International Journal of Molecular Sciences, 25(17), 9541. https://doi.org/10.3390/ijms25179541

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