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Dental Health and Disease: From the Molecular and Pathological Perspectives
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Dental Health and Disease: From the Molecular and Pathological Perspectives

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 25 October 2024 | Viewed by 1486

Special Issue Editors

Dr. Ancuţa Goriuc

E-Mail Website
Guest Editor
Department of Biochemistry, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115 Iasi, Romania
Interests: apoptosis and gingival overgrowth; periodontal disease; metalloproteinases; dentistry
Dr. Ionut Luchian

E-Mail Website
Guest Editor
Department of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Interests: salivary research; ortho-perio; cytokines; biomarkers; finite element method; periodontology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to promote molecular and pathophysiological research in the field of oral health and diseases, aiming for better treatment approaches.

We all know that the health of the oral cavity plays a crucial role in maintaining an equilibrium concerning the overall health of patients. Nowadays, there is a strong focus on oral health issues, particularly their prevention. Oral health varies throughout life, but it is imperative to recognize its connection to general health. In addition to serving essential functions such as eating, breathing, speaking, and the ability to socialize, oral health contributes significantly to fostering self-confidence, thereby acquiring psychosocial dimensions.

In recent years, research in this field has been directed towards gaining a more profound understanding of the molecular and pathophysiological mechanisms underlying oral cavity conditions. Comprehensive knowledge and reevaluation of both the molecular mechanisms that contribute to good oral health and those contributing to the development of oral diseases are essential for more effective prevention, diagnosis, and treatment of these conditions.

It is worth noting that progress in this direction necessitates the sustained involvement of specialists from various fields, including physiopathology, biochemistry, microbiology, and dentistry, as research teams.

Thus, both original and review papers that respect the topic of this Special Issue are welcome to be submitted.

Dr. Ancuţa Goriuc
Dr. Ionut Luchian
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental health
  • oral diseases
  • molecular mechanisms
  • pathological mechanisms
  • treatment perspectives
  • dentistry
  • oral medicine
  • oral pathology
  • physiopathology in dentistry
  • periodontal disease
  • oral fluids
 

Published Papers (2 papers)

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Research

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32 pages, 14743 KiB  
Article
Streptococcus gordonii Supragingival Bacterium Oral Infection-Induced Periodontitis and Robust miRNA Expression Kinetics
by Chairmandurai Aravindraja, Syam Jeepipalli, William D. Duncan, Krishna Mukesh Vekariya, Shaik O. Rahaman, Edward K. L. Chan and Lakshmyya Kesavalu
Int. J. Mol. Sci. 2024, 25(11), 6217; https://doi.org/10.3390/ijms25116217 - 5 Jun 2024
Viewed by 582
Abstract
Streptococcus gordonii (S. gordonii, Sg) is one of the early colonizing, supragingival commensal bacterium normally associated with oral health in human dental plaque. MicroRNAs (miRNAs) play an important role in the inflammation-mediated pathways and are involved in periodontal disease (PD) pathogenesis. [...] Read more.
Streptococcus gordonii (S. gordonii, Sg) is one of the early colonizing, supragingival commensal bacterium normally associated with oral health in human dental plaque. MicroRNAs (miRNAs) play an important role in the inflammation-mediated pathways and are involved in periodontal disease (PD) pathogenesis. PD is a polymicrobial dysbiotic immune-inflammatory disease initiated by microbes in the gingival sulcus/pockets. The objective of this study is to determine the global miRNA expression kinetics in S. gordonii DL1-infected C57BL/6J mice. All mice were randomly divided into four groups (n = 10 mice/group; 5 males and 5 females). Bacterial infection was performed in mice at 8 weeks and 16 weeks, mice were euthanized, and tissues harvested for analysis. We analyzed differentially expressed (DE) miRNAs in the mandibles of S. gordonii-infected mice. Gingival colonization/infection by S. gordonii and alveolar bone resorption (ABR) was confirmed. All the S. gordonii-infected mice at two specific time points showed bacterial colonization (100%) in the gingival surface, and a significant increase in mandible and maxilla ABR (p < 0.0001). miRNA profiling revealed 191 upregulated miRNAs (miR-375, miR-34b-5p) and 22 downregulated miRNAs (miR-133, miR-1224) in the mandibles of S. gordonii-infected mice at the 8-week mark. Conversely, at 16 weeks post-infection, 10 miRNAs (miR-1902, miR-203) were upregulated and 32 miRNAs (miR-1937c, miR-720) were downregulated. Two miRNAs, miR-210 and miR-423-5p, were commonly upregulated, and miR-2135 and miR-145 were commonly downregulated in both 8- and 16-week-infected mice mandibles. Furthermore, we employed five machine learning (ML) algorithms to assess how the number of miRNA copies correlates with S. gordonii infections in mice. In the ML analyses, miR-22 and miR-30c (8-week), miR-720 and miR-339-5p (16-week), and miR-720, miR-22, and miR-339-5p (combined 8- and 16-week) emerged as the most influential miRNAs. Full article
(This article belongs to the Special Issue Dental Health and Disease: From the Molecular and Pathological Perspectives)
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20 pages, 1121 KiB  
Review
The Bloody Crossroads: Interactions between Periodontitis and Hematologic Diseases
by Michał Łobacz, Paulina Mertowska, Sebastian Mertowski, Aleksandra Kozińska, Wojciech Kwaśniewski, Marek Kos, Ewelina Grywalska and Mansur Rahnama-Hezavah
Int. J. Mol. Sci. 2024, 25(11), 6115; https://doi.org/10.3390/ijms25116115 - 1 Jun 2024
Viewed by 486
Abstract
Periodontitis is a common oral condition that can have a significant impact on the overall health of the body. In recent years, attention has been paid to potential relationships between periodontitis and various hematological disorders. This publication aims to present information available in [...] Read more.
Periodontitis is a common oral condition that can have a significant impact on the overall health of the body. In recent years, attention has been paid to potential relationships between periodontitis and various hematological disorders. This publication aims to present information available in the literature on this relationship, focusing on examples of red blood cell disorders (such as aplastic anemia and sickle cell anemia) and white blood cell disorders (such as cyclic neutropenia, maladaptive trained immunity, clonal hematopoiesis, leukemia, and multiple myeloma). Understanding these associations can help physicians and dentists better diagnose, monitor, and treat patients associated with both groups of conditions, highlighting the need for interdisciplinary care for patients with oral disorders and hematologic diseases. Full article
(This article belongs to the Special Issue Dental Health and Disease: From the Molecular and Pathological Perspectives)
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