Revolutionizing Bone Regeneration with Grinder-Based Dentin Biomaterial: A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Focus Question
2.2. Protocol
2.3. Eligibility Criteria
2.4. Information Sources, Search Strategy, and Study Selection
2.5. Data Collection Process and Data Items
2.6. Quality Assessment
3. Results
3.1. Study Selection
3.2. Molecular Aspects of Ground Dentin Grafts
3.2.1. Chemical Composition
3.2.2. Evaluation of Cellular Responses
3.3. Morphology
3.4. Histomorphometric Outcomes
3.5. Bacteriological Purity
3.6. Clinical Outcomes
3.6.1. Bone Tissue Regeneration
3.6.2. Periprocedural and Long-Term Complications
3.6.3. Patients’ Reported Outcomes
3.7. Quality Assessment
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Inclusion Criteria | Exclusion Criteria | |
---|---|---|
Population | Human studies, regardless of the age of the participants, experimental models, and in vitro studies | |
Intervention | Dentin biomaterial used for bone regeneration produced with the dentin grinder | Dentin crushed or trimmed by other methods |
Comparators | Any procedure of bone regeneration or none | |
Outcomes of interest | Any | The technical aspect of material harvesting without investigating its biological activity and molecular aspects |
Study designs | Clinical trials involving humans Case reports | Reviews Letters Technical report Proof-of-concept studies |
Author | Study Design | Study Material */Tissue | Outcomes | |
---|---|---|---|---|
Physicochemical/Molecular | Clinical | |||
Bianchi, 2021 [20] | In vitro; 4 teeth from 1 donor | Mineralized dentin (human) Deproteinized and demineralized dentin Demineralized dentin Deproteinized bovine bone Tissue: cell lines: human periodontal ligament fibroblasts |
|
|
Khanijou et al., 2021 [21] | In vitro; 12 teeth | Tooth-derived bone substitute (human) Allografts (OraGRAFT, DO BONE) Xenograft (BioOss) Alloplast (BoneCeramic) Human mandibular ramus bone Tissue: cell lines: human fetal osteoblastic cells |
|
|
Sarna-Boś et al., 2022 [22] | In vitro; 50 teeth 50 donors | Four groups (incisors, canines, premolars, molars) crushed without chemical processing |
|
|
Binderman et al., 2014 [15] | 2 cases | Autogenous mineralized dentin matrix Tissue: alveolar bone regeneration after extraction |
|
|
Cervera-Maillo et al., 2021 [23] | 10 patients | Autologous dentin with platelet-rich plasma Tissue: alveolar bone after tooth extraction |
|
|
De Biase et al., 2020 [17] | Split-month case report | Autologous demineralized dentin matrix Tissue: alveolar bone regeneration after extraction |
|
|
Del Canto-Díaz et al., 2019 [27] | 9 patients; split-mouth study | Autologous dental material Unfilled extraction sockets Tissue: alveolar bone regeneration after extraction |
|
|
Dłucik et al., 2023 [24] | 21 patients in the SDG group | Autologous demineralized dentin matrix Tissue: alveolar bone regeneration after extraction, Sinus lift procedure |
|
|
Dłucik et al., 2023 [28] | 13 patients in the SDG group | Autologous demineralized dentin matrix Tissue: alveolar bone regeneration after extraction |
|
|
Matsuzawa et al., 2022 [25] | Case report | Autologous demineralized dentin matrix (primary teeth) Tissue: unilateral alveolar cleft |
|
|
Pohl et al., 2020 [26] | 12 patients; 58 sockets | Autologous mineralized dentin with platelet-rich plasma Tissue: alveolar bone after tooth extraction |
|
|
Santos et al., 2021 [14] | 52 patients; 66 implants | Autogenous mineralized dentin matrix Xenograft granules |
|
|
Jun et al., 2014 [29] | 38 patients; 19 Bio-Oss; 19 AutoBT | Autogenous tooth bone graft (AutoBT) Xenograft (BioOss) |
|
|
Case Reports | Binderman [15] | De Biase [17] | Matsuzawa [25] |
Were the patient’s demographic characteristics clearly described? | No | Yes | Yes |
Was the patient’s history clearly described and presented as a timeline? | No | Yes | Yes |
Was the current clinical condition of the patient on presentation clearly described? | Yes | Yes | Yes |
Were diagnostic tests or assessment methods and the results clearly described? | Yes | Yes | Yes |
Was the intervention(s) or treatment procedure(s) clearly described? | Yes | Yes | Yes |
Was the post-intervention clinical condition clearly described? | Yes | Yes | Yes |
Were adverse events (harms) or unanticipated events identified and described? | Yes | No | Yes |
Does the case report provide takeaway lessons? | Yes | No | Yes |
Case Series | Pohl [26] | ||
Were there clear criteria for inclusion in the case series? | Yes | ||
Was the condition measured in a standard, reliable way for all participants included in the case series? | Yes | ||
Were valid methods used for the identification of the condition for all participants included in the case series? | Yes | ||
Did the case series have consecutive inclusion of participants? | Yes | ||
Did the case series have a complete inclusion of participants? | Yes | ||
Was there clear reporting of the demographics of the participants in the study? | No | ||
Was there clear reporting of the clinical information of the participants? | Yes | ||
Were the outcomes or follow-up results of cases clearly reported? | Yes | ||
Was there clear reporting of the presenting site(s)/clinic(s) demographic information? | Yes | ||
Was statistical analysis appropriate? | Yes | ||
Cohort Studies | Cervera-Maillo [23] | ||
Were the two groups similar and recruited from the same population? | Yes | ||
Were the exposures measured similarly to assign people to both exposed and unexposed groups? | Yes | ||
Was the exposure measured in a valid and reliable way? | Yes | ||
Were confounding factors identified? | No | ||
Were strategies to deal with confounding factors stated? | No | ||
Were the groups/participants free of the outcome at the start of the study (or at the moment of exposure)? | Yes | ||
Were the outcomes measured in a valid and reliable way? | Yes | ||
Was the follow-up time reported and sufficient to be long enough for outcomes to occur? | Yes | ||
Was the follow up complete, and if not, were the reasons for the loss of follow-up described and explored? | Yes | ||
Were strategies to address incomplete follow-up utilized? | NA | ||
Was appropriate statistical analysis used? | Yes | ||
Randomized Controlled Trials | Santos [14] | Jun [29] | |
Was true randomization used for the assignment of participants to treatment groups? | Yes | Yes | |
Was allocation to treatment groups concealed? | Yes | Unclear | |
Were treatment groups similar at the baseline? | Yes | Yes | |
Were participants blind to treatment assignment? | Yes | Unclear | |
Were those delivering the treatment blind to treatment assignment? | No | Unclear | |
Were treatment groups treated identically other than the intervention of interest? | Yes | Yes | |
Were outcome assessors blind to treatment assignment? | Yes | Unclear | |
Were outcomes measured in the same way for treatment groups? | Yes | Yes | |
Were outcomes measured in a reliable way? | Yes | Yes | |
Was follow-up complete, and if not, were differences between groups in terms of their follow-up adequately described and analyzed? | Yes | Unclear | |
Were participants analyzed in the groups to which they were randomized? | Yes | Yes | |
Was appropriate statistical analysis used? | Yes | Yes | |
Was the trial design appropriate and were any deviations from the standard RCT design accounted for in the conduct and analysis of the trial? | Unclear | Unclear |
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Olchowy, A.; Olchowy, C.; Zawiślak, I.; Matys, J.; Dobrzyński, M. Revolutionizing Bone Regeneration with Grinder-Based Dentin Biomaterial: A Systematic Review. Int. J. Mol. Sci. 2024, 25, 9583. https://doi.org/10.3390/ijms25179583
Olchowy A, Olchowy C, Zawiślak I, Matys J, Dobrzyński M. Revolutionizing Bone Regeneration with Grinder-Based Dentin Biomaterial: A Systematic Review. International Journal of Molecular Sciences. 2024; 25(17):9583. https://doi.org/10.3390/ijms25179583
Chicago/Turabian StyleOlchowy, Anna, Cyprian Olchowy, Ireneusz Zawiślak, Jacek Matys, and Maciej Dobrzyński. 2024. "Revolutionizing Bone Regeneration with Grinder-Based Dentin Biomaterial: A Systematic Review" International Journal of Molecular Sciences 25, no. 17: 9583. https://doi.org/10.3390/ijms25179583