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Article

The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women

by
Jana Vitku
1,*,
Anezka Varausova
1,
Tereza Skodova
1,
Lucie Kolatorova
1,
Michala Vosatkova
2,
Josef Vcelak
3,
Jana Vrbikova
4,
Marketa Simkova
1 and
Michaela Svojtkova
1
1
Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic
2
Department of Clinical Biochemistry, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic
3
Department of Molecular Endocrinology, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic
4
Department of Clinical Endocrinology, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(17), 9691; https://doi.org/10.3390/ijms25179691
Submission received: 26 July 2024 / Revised: 29 August 2024 / Accepted: 4 September 2024 / Published: 7 September 2024
(This article belongs to the Special Issue Molecular Insights in Steroid Biosynthesis and Metabolism)
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Abstract

Polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH) are androgen excess disorders requiring the determination of classic androgen levels for diagnosis. 11-oxygenated androgens have high androgenic potential, yet their clinical value in those disorders is not clear. Additionally, the role of endocrine disruptors (EDs), particularly in IH, remains understudied. We analyzed 25 steroids and 18 EDs in plasma samples from women with IH, PCOS, and controls using LC-MS/MS. Cytokine levels and metabolic parameters were assessed. Comparisons included non-obese women with PCOS (n = 10), women with IH (n = 12) and controls (n = 20), and non-obese versus obese women with PCOS (n = 9). Higher levels of 11-oxygenated androgens were observed in women with PCOS compared to those with IH, but not controls. Conversely, 11-oxygenated androgen levels were lower in women with IH compared to controls. Cytokine levels did not differ between women with IH and controls. Bisphenol A (BPA) levels were higher in obese women with PCOS compared to non-obese women with PCOS. Bisphenol S occurrence was higher in women with PCOS (90%) compared to controls (65%) and IH (50%). Significant correlations were found between androgens (11-ketotestosterone, androstenedione, testosterone) and insulin and HOMA-IR, as well as between immunomodulatory 7-oxygenated metabolites of DHEA and nine interleukins. Our data confirms that PCOS is a multiendocrine gland disorder. Higher BPA levels in obese women might exacerbate metabolic abnormalities. IH was not confirmed as an inflammatory state, and no differences in BPA levels suggest BPA does not play a role in IH pathogenesis.
Keywords: polycystic ovary syndrome; idiopathic hirsutism; endocrine disruptor; bisphenol A; bisphenol S; 11-oxygenated androgen; 11-ketotestosterone; 11-hydroxytestosterone polycystic ovary syndrome; idiopathic hirsutism; endocrine disruptor; bisphenol A; bisphenol S; 11-oxygenated androgen; 11-ketotestosterone; 11-hydroxytestosterone

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MDPI and ACS Style

Vitku, J.; Varausova, A.; Skodova, T.; Kolatorova, L.; Vosatkova, M.; Vcelak, J.; Vrbikova, J.; Simkova, M.; Svojtkova, M. The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women. Int. J. Mol. Sci. 2024, 25, 9691. https://doi.org/10.3390/ijms25179691

AMA Style

Vitku J, Varausova A, Skodova T, Kolatorova L, Vosatkova M, Vcelak J, Vrbikova J, Simkova M, Svojtkova M. The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women. International Journal of Molecular Sciences. 2024; 25(17):9691. https://doi.org/10.3390/ijms25179691

Chicago/Turabian Style

Vitku, Jana, Anezka Varausova, Tereza Skodova, Lucie Kolatorova, Michala Vosatkova, Josef Vcelak, Jana Vrbikova, Marketa Simkova, and Michaela Svojtkova. 2024. "The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women" International Journal of Molecular Sciences 25, no. 17: 9691. https://doi.org/10.3390/ijms25179691

APA Style

Vitku, J., Varausova, A., Skodova, T., Kolatorova, L., Vosatkova, M., Vcelak, J., Vrbikova, J., Simkova, M., & Svojtkova, M. (2024). The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women. International Journal of Molecular Sciences, 25(17), 9691. https://doi.org/10.3390/ijms25179691

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