A Compendium of G-Flipon Biological Functions That Have Experimental Validation
Abstract
:1. Introduction
2. Biophysical and Computational Studies of the G-Quadruplex
3. GQ-Binding Proteins
4. The Accumulating Evidence for the Biological Importance of G-Quadruplexes
4.1. Retroviral Latency
4.2. Cell Division
4.3. Epigenetic Maintenance
4.4. DNA Replication and Sister Chromatid Conformation
4.5. Nucleotide Excision Repair (NER)
4.6. Base Excision Repair (BER)
4.7. Hemin and Oxidative Damage
4.8. Telomere Protection
4.9. Resolution of G-Quadruplexes
4.10. G-Flipons and Gene Expression
4.11. Enhancer Promoter Condensates
4.12. Transcriptional Bursting
4.13. Promoter Pausing
4.14. G- and Z-Flipons and Promoter Reset
4.15. Gene Repression
4.16. R Loop Resolution
4.17. Chromatin Loops and Transcript Elongation
4.18. Chromatin Loops and Splicing
5. RNA and G-Quadruplexes
5.1. RNA Modifications and Splicing
5.2. Ribosome Assembly
5.3. Translation
6. Flipons and Development
6.1. Pioneering Factors and Flipons
6.2. Bootstrapping Flipon Conformation with Noncoding RNAs
7. Summary and Outlook
Funding
Conflicts of Interest
References
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Herbert, A. A Compendium of G-Flipon Biological Functions That Have Experimental Validation. Int. J. Mol. Sci. 2024, 25, 10299. https://doi.org/10.3390/ijms251910299
Herbert A. A Compendium of G-Flipon Biological Functions That Have Experimental Validation. International Journal of Molecular Sciences. 2024; 25(19):10299. https://doi.org/10.3390/ijms251910299
Chicago/Turabian StyleHerbert, Alan. 2024. "A Compendium of G-Flipon Biological Functions That Have Experimental Validation" International Journal of Molecular Sciences 25, no. 19: 10299. https://doi.org/10.3390/ijms251910299