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Open AccessArticle
Enhanced Photodynamic Therapy Efficacy through Solid Lipid Nanoparticle of Purpurin-18-N-Propylimide Methyl Ester for Cancer Treatment
by
Sooho Yeo
Sooho Yeo 1,2,†,
Huiqiang Wu
Huiqiang Wu 2,†,
Il Yoon
Il Yoon 2,
Hye-Soo Kim
Hye-Soo Kim 1,
Young Kyu Song
Young Kyu Song 3,* and
Woo Kyoung Lee
Woo Kyoung Lee 2,*
1
Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Republic of Korea
2
Center for Nano Manufacturing and Department of Nanoscience and Engineering, Inje University, Gimhae 50834, Republic of Korea
3
Research Center of Dr. i&B Co., Daejeon 34047, Republic of Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(19), 10382; https://doi.org/10.3390/ijms251910382 (registering DOI)
Submission received: 2 September 2024
/
Revised: 20 September 2024
/
Accepted: 24 September 2024
/
Published: 26 September 2024
Abstract
Photodynamic therapy (PDT) is an innovative cancer treatment that utilizes light. When light irradiates, purpurin-18-N-propylimide methyl ester (P18 N PI ME) generates reactive oxygen species that destroy cancer cells. The hydrophobic nature of P18 N PI ME presents challenges regarding its aggregation in the body, which can affect its effectiveness. This study aimed to enhance the bioavailability and effectiveness of cancer treatment by synthesizing P18 N PI ME and formulating P18 N PI ME-loaded solid lipid nanoparticles (SLNs). The efficacy of PDT was estimated using the 1,3-diphenylisobenzofuran (DPBF) assay and photocytotoxicity tests on the HeLa (human cervical carcinoma) and A549 (human lung carcinoma) cell lines. The P18 N PI ME-loaded SLNs demonstrated particle sizes in the range of 158.59 nm to 248.43 nm and zeta potentials in the range of –15.97 mV to –28.73 mV. These SLNs exhibited sustained release of P18 N PI ME. DPBF analysis revealed enhanced PDT effects with SLNs containing P18 N PI ME compared with standalone P18 N PI MEs. Photocytotoxicity assays indicated toxicity under light irradiation but no toxicity in the dark. Furthermore, the smallest-sized formulation exhibited the most effective photodynamic activity. These findings indicate the potential of P18 N PI ME-loaded SLNs as promising strategies for PDT in cancer therapy.
Share and Cite
MDPI and ACS Style
Yeo, S.; Wu, H.; Yoon, I.; Kim, H.-S.; Song, Y.K.; Lee, W.K.
Enhanced Photodynamic Therapy Efficacy through Solid Lipid Nanoparticle of Purpurin-18-N-Propylimide Methyl Ester for Cancer Treatment. Int. J. Mol. Sci. 2024, 25, 10382.
https://doi.org/10.3390/ijms251910382
AMA Style
Yeo S, Wu H, Yoon I, Kim H-S, Song YK, Lee WK.
Enhanced Photodynamic Therapy Efficacy through Solid Lipid Nanoparticle of Purpurin-18-N-Propylimide Methyl Ester for Cancer Treatment. International Journal of Molecular Sciences. 2024; 25(19):10382.
https://doi.org/10.3390/ijms251910382
Chicago/Turabian Style
Yeo, Sooho, Huiqiang Wu, Il Yoon, Hye-Soo Kim, Young Kyu Song, and Woo Kyoung Lee.
2024. "Enhanced Photodynamic Therapy Efficacy through Solid Lipid Nanoparticle of Purpurin-18-N-Propylimide Methyl Ester for Cancer Treatment" International Journal of Molecular Sciences 25, no. 19: 10382.
https://doi.org/10.3390/ijms251910382
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