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Article

Contribution of the Mobilome to the Configuration of the Resistome of Corynebacterium striatum

by
Catherine Urrutia
1,2,
Benjamin Leyton-Carcaman
1,3 and
Michel Abanto Marin
1,*
1
Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco 4811230, Chile
2
Carrera de Biotecnología, Facultad de Ciencias Agropecuarias y Medioambiente, Universidad de La Frontera, Temuco 4811230, Chile
3
Doctorado en Ciencias Mención Biología Celular y Molecular Aplicada, Universidad de La Frontera, Temuco 4811230, Chile
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(19), 10499; https://doi.org/10.3390/ijms251910499 (registering DOI)
Submission received: 8 September 2024 / Revised: 26 September 2024 / Accepted: 27 September 2024 / Published: 29 September 2024
(This article belongs to the Special Issue Evolution and Genomics: Relevance to Current Issues)

Abstract

Corynebacterium striatum, present in the microbiota of human skin and nasal mucosa, has recently emerged as a causative agent of hospital-acquired infections, notable for its resistance to multiple antimicrobials. Its mobilome comprises several mobile genetic elements, such as plasmids, transposons, insertion sequences and integrons, which contribute to the acquisition of antimicrobial resistance genes. This study analyzes the contribution of the C. striatum mobilome in the transfer and dissemination of resistance genes. In addition, integrative and conjugative elements (ICEs), essential in the dissemination of resistance genes between bacterial populations, whose role in C. striatum has not yet been studied, are examined. This study examined 365 C. striatum genomes obtained from the NCBI Pathogen Detection database. Phylogenetic and pangenome analyses were performed, the resistance profile of the bacterium was recognized, and mobile elements, including putative ICE, were detected. Bioinformatic analyses identified 20 antimicrobial resistance genes in this species, with the Ermx gene being the most predominant. Resistance genes were mainly associated with plasmid sequence regions and class 1 integrons. Although an ICE was detected, no resistance genes linked to this element were found. This study provided valuable information on the geographic spread and prevalence of outbreaks observed through phylogenetic and pangenome analyses, along with identifying antimicrobial resistance genes and mobile genetic elements that carry many of the resistance genes and may be the subject of future research and therapeutic approaches.
Keywords: Corynebacterium striatum; mobilome; mobile genetic elements; antimicrobial resistance; integrative and conjugative elements (ICEs) Corynebacterium striatum; mobilome; mobile genetic elements; antimicrobial resistance; integrative and conjugative elements (ICEs)

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MDPI and ACS Style

Urrutia, C.; Leyton-Carcaman, B.; Marin, M.A. Contribution of the Mobilome to the Configuration of the Resistome of Corynebacterium striatum. Int. J. Mol. Sci. 2024, 25, 10499. https://doi.org/10.3390/ijms251910499

AMA Style

Urrutia C, Leyton-Carcaman B, Marin MA. Contribution of the Mobilome to the Configuration of the Resistome of Corynebacterium striatum. International Journal of Molecular Sciences. 2024; 25(19):10499. https://doi.org/10.3390/ijms251910499

Chicago/Turabian Style

Urrutia, Catherine, Benjamin Leyton-Carcaman, and Michel Abanto Marin. 2024. "Contribution of the Mobilome to the Configuration of the Resistome of Corynebacterium striatum" International Journal of Molecular Sciences 25, no. 19: 10499. https://doi.org/10.3390/ijms251910499

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