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Evolution and Genomics: Relevance to Current Issues

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 515

Special Issue Editors


E-Mail Website
Guest Editor
C.Y. O'Connor ERADE Village Foundation, Perth, Australia
Interests: evolution; immunogenetics; genomics; ancestral haplotypes; speciation and individuality; cattle; muscle; olfaction

E-Mail Website
Guest Editor
C.Y. O'Connor ERADE Village Foundation, North Dandalup, WA 6207, Australia
Interests: livestock genetics; evolution; retrotransposons; mathematical modelling

Special Issue Information

Dear Colleagues,

The theme of original papers of this Special Issue is to demonstrate how new ideas can be relevant to those attempting to solve a problem or participating in popular debates. Topics of interest in this Special Issue include, but are not limited to, the following:

  • Effects of past and future climate change on human evolution.
  • Pros and cons of inbreeding, introgression, and selective diversification in livestock.
  • Mechanisms of suppression of mutation and recombination with reference to future populations.
  • Definition of conserved polymorphic sequences.
  • Re-interpretation of commercial databases for genomics: haplotypes from SNPs.
  • What to conserve for the future: old or new?
  • Synteny and paralogy and duplication in evolution.
  • Microbiome in evolution.
  • The MHC as the frontier for evolution.
  • Refreshing terminology in evolution.

Prof. Dr. Roger Dawkins
Dr. Sally Lloyd
Guest Editors

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Keywords

  • paralogy
  • synteny
  • evolution
  • genomics
  • duplication
  • haplotype

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Published Papers (1 paper)

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Research

15 pages, 2600 KiB  
Article
Contribution of the Mobilome to the Configuration of the Resistome of Corynebacterium striatum
by Catherine Urrutia, Benjamin Leyton-Carcaman and Michel Abanto Marin
Int. J. Mol. Sci. 2024, 25(19), 10499; https://doi.org/10.3390/ijms251910499 - 29 Sep 2024
Viewed by 399
Abstract
Corynebacterium striatum, present in the microbiota of human skin and nasal mucosa, has recently emerged as a causative agent of hospital-acquired infections, notable for its resistance to multiple antimicrobials. Its mobilome comprises several mobile genetic elements, such as plasmids, transposons, insertion sequences [...] Read more.
Corynebacterium striatum, present in the microbiota of human skin and nasal mucosa, has recently emerged as a causative agent of hospital-acquired infections, notable for its resistance to multiple antimicrobials. Its mobilome comprises several mobile genetic elements, such as plasmids, transposons, insertion sequences and integrons, which contribute to the acquisition of antimicrobial resistance genes. This study analyzes the contribution of the C. striatum mobilome in the transfer and dissemination of resistance genes. In addition, integrative and conjugative elements (ICEs), essential in the dissemination of resistance genes between bacterial populations, whose role in C. striatum has not yet been studied, are examined. This study examined 365 C. striatum genomes obtained from the NCBI Pathogen Detection database. Phylogenetic and pangenome analyses were performed, the resistance profile of the bacterium was recognized, and mobile elements, including putative ICE, were detected. Bioinformatic analyses identified 20 antimicrobial resistance genes in this species, with the Ermx gene being the most predominant. Resistance genes were mainly associated with plasmid sequence regions and class 1 integrons. Although an ICE was detected, no resistance genes linked to this element were found. This study provided valuable information on the geographic spread and prevalence of outbreaks observed through phylogenetic and pangenome analyses, along with identifying antimicrobial resistance genes and mobile genetic elements that carry many of the resistance genes and may be the subject of future research and therapeutic approaches. Full article
(This article belongs to the Special Issue Evolution and Genomics: Relevance to Current Issues)
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