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Induced Necroptosis and Its Role in Cancer Immunotherapy
by
Ziyao Zhang
Ziyao Zhang 1,†,
Fangming Zhang
Fangming Zhang 1,†,
Wenjing Xie
Wenjing Xie 2,
Yubo Niu
Yubo Niu 1,
Haonan Wang
Haonan Wang 1,
Guofeng Li
Guofeng Li
Prof. Dr. Guofeng Li obtained his master's degree from the School of Life Science and Technology, of [...]
Prof. Dr. Guofeng Li obtained his master's degree from the School of Life Science and Technology, Beijing University of Chemical Technology, in 2011–2014 and his doctoral degree in 2014–2017. From May 2018 to April 2021, he worked as a postdoctoral/lecturer in the School of Life Sciences and Technology at Beijing University of Chemical Technology. Since May 2021, he has been serving as an associate professor at the School of Life Sciences and Technology, Beijing University of Chemical Technology. He is a member of the Forum on Antimicrobial Science and Technology.
1,
Lingyun Zhao
Lingyun Zhao 3,
Xing Wang
Xing Wang
Prof. Dr. Xing Wang obtained his PhD in science from Jilin University from September 2001 to July to [...]
Prof. Dr. Xing Wang obtained his PhD in science from Jilin University from September 2001 to July 2006. From December 2006 to October 2011, he worked as a postdoctoral fellow at the Physics Institute of the University of Münster in Germany. From December 2011 to the present, he has been serving as an associate professor at the School of Life Sciences and Technology, Beijing University of Chemical Technology. From September 2013 to the present, he has been serving as a doctoral supervisor at the School of Life Sciences and Technology, Beijing University of Chemical Technology. His main research direction is chiral function and intelligent polymers, studying the effects of chiral materials on biological systems and surface interface issues, as well as their applications in the biomedical field.
1,* and
Wensheng Xie
Wensheng Xie 1,*
1
The Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
2
School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, China
3
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally.
Int. J. Mol. Sci. 2024, 25(19), 10760; https://doi.org/10.3390/ijms251910760 (registering DOI)
Submission received: 5 August 2024
/
Revised: 30 August 2024
/
Accepted: 4 October 2024
/
Published: 6 October 2024
Abstract
Necroptosis is a type of regulated cell death (RCD) that is triggered by changes in the extracellular or intracellular milieu that are picked up by certain death receptors. Thanks to its potent capacity to induce immunological responses and overcome apoptotic resistance, it has garnered significant attention as a potential cancer treatment. Basic information for the creation of nano-biomedical treatments is provided by studies on the mechanisms underlying tumor necroptosis. Receptor-interacting protein kinase 1 (RIPK1)–RIPK3-mediated necroptosis, Toll-like receptor domain-containing adapter-inducing interferon (IFN)-β (TRIF)–RIPK3-mediated necroptosis, Z-DNA-binding protein 1 (ZBP1)–RIPK3-mediated necroptosis, and IFNR-mediated necroptosis are the four signaling pathways that collectively account for triggered necroptosis in this review. Necroptosis has garnered significant interest as a possible cancer treatment strategy because, in contrast to apoptosis, it elicits immunological responses that are relevant to therapy. Thus, a thorough discussion is held on the connections between tumor cell necroptosis and the immune environment, cancer immunosurveillance, and cells such as dendritic cells (DCs), cytotoxic T cells, natural killer (NK) cells, natural killer T (NKT) cells, and their respective cytokines. Lastly, a summary of the most recent nanomedicines that cause necroptosis in order to cause immunogenic cell death is provided in order to emphasize their promise for cancer immunotherapy.
Share and Cite
MDPI and ACS Style
Zhang, Z.; Zhang, F.; Xie, W.; Niu, Y.; Wang, H.; Li, G.; Zhao, L.; Wang, X.; Xie, W.
Induced Necroptosis and Its Role in Cancer Immunotherapy. Int. J. Mol. Sci. 2024, 25, 10760.
https://doi.org/10.3390/ijms251910760
AMA Style
Zhang Z, Zhang F, Xie W, Niu Y, Wang H, Li G, Zhao L, Wang X, Xie W.
Induced Necroptosis and Its Role in Cancer Immunotherapy. International Journal of Molecular Sciences. 2024; 25(19):10760.
https://doi.org/10.3390/ijms251910760
Chicago/Turabian Style
Zhang, Ziyao, Fangming Zhang, Wenjing Xie, Yubo Niu, Haonan Wang, Guofeng Li, Lingyun Zhao, Xing Wang, and Wensheng Xie.
2024. "Induced Necroptosis and Its Role in Cancer Immunotherapy" International Journal of Molecular Sciences 25, no. 19: 10760.
https://doi.org/10.3390/ijms251910760
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