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Volume 25
Issue 23
10.3390/ijms252312763
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Analysis of CD1a-Positive Monocyte-Derived Cells in the Regional Lymph Nodes of Patients with Gallbladder Cancer

by
Sachiko Maeda
1,2,
Keita Kai
3,*,
Kanako Kawasaki
1,
Tomokazu Tanaka
2,
Takao Ide
2 and
Hirokazu Noshiro
2
1
Department of Pathology & Microbiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan
2
Department of Surgery, Faculty of Medicine, Saga University, Saga 849-8501, Japan
3
Department of Pathology, Saga University Hospital, Saga 849-8501, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(23), 12763; https://doi.org/10.3390/ijms252312763
Submission received: 7 November 2024 / Revised: 24 November 2024 / Accepted: 26 November 2024 / Published: 27 November 2024
(This article belongs to the Special Issue New Insights in Tumor Immunity)
Review Reports Versions Notes

Abstract

Dendritic cells (DCs) are known to be major antigen-presenting cells, and lymph nodes (LNs) play an important role in DC-mediated immune response. CD1a is known as a marker of monocyte-derived DCs. The present study focused on the infiltration of CD1a-positive DCs (CD1a-DCs) into regional LNs in 70 cases of gallbladder cancer (GBC). After univariate analyses, the results showed that LN infiltration by CD1a-DCs was associated with unfavorable clinical outcomes in patients with GBC, with all cases categorized in the CD1a-DCs high group had nodal metastasis. LN infiltration by CD1a-DCs was not an independent prognostic factor identified by multivariate analyses. After subgroup analyses of cases with LN metastasis (n = 32), no significant impacts of CD1a-DCs infiltration into metastatic LNs were observed. In contrast, CD1a-DCs infiltration into primary tumors had a significant impact on surgical outcomes. The results of strong confounding between CD1a-DCs and LN metastasis support the theory that CD1a-DCs are developed from monocytes at tumor sites. As the results of previous research focused on CD1a-DCs infiltration into regional LNs of other organs varied, the role and significance of CD1a-DCs infiltration in regional LNs may be different according to the tumor histology or its primary site. Thus, further studies are needed to clarify the role and significance of CD1a-DCs infiltration into regional LNs of solid cancers.
Keywords: dendritic cell; CD1a; monocyte; lymph node; gallbladder cancer dendritic cell; CD1a; monocyte; lymph node; gallbladder cancer

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MDPI and ACS Style

Maeda, S.; Kai, K.; Kawasaki, K.; Tanaka, T.; Ide, T.; Noshiro, H. Analysis of CD1a-Positive Monocyte-Derived Cells in the Regional Lymph Nodes of Patients with Gallbladder Cancer. Int. J. Mol. Sci. 2024, 25, 12763. https://doi.org/10.3390/ijms252312763

AMA Style

Maeda S, Kai K, Kawasaki K, Tanaka T, Ide T, Noshiro H. Analysis of CD1a-Positive Monocyte-Derived Cells in the Regional Lymph Nodes of Patients with Gallbladder Cancer. International Journal of Molecular Sciences. 2024; 25(23):12763. https://doi.org/10.3390/ijms252312763

Chicago/Turabian Style

Maeda, Sachiko, Keita Kai, Kanako Kawasaki, Tomokazu Tanaka, Takao Ide, and Hirokazu Noshiro. 2024. "Analysis of CD1a-Positive Monocyte-Derived Cells in the Regional Lymph Nodes of Patients with Gallbladder Cancer" International Journal of Molecular Sciences 25, no. 23: 12763. https://doi.org/10.3390/ijms252312763

APA Style

Maeda, S., Kai, K., Kawasaki, K., Tanaka, T., Ide, T., & Noshiro, H. (2024). Analysis of CD1a-Positive Monocyte-Derived Cells in the Regional Lymph Nodes of Patients with Gallbladder Cancer. International Journal of Molecular Sciences, 25(23), 12763. https://doi.org/10.3390/ijms252312763

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