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Volume 25
Issue 4
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Article
Peer-Review Record

CD163-Mediated Small-Vessel Injury in Alzheimer’s Disease: An Exploration from Neuroimaging to Transcriptomics

Int. J. Mol. Sci. 2024, 25(4), 2293; https://doi.org/10.3390/ijms25042293
by Yuewei Chen 1,2,3,†, Peiwen Lu 1,3,†, Shengju Wu 4, Jie Yang 1,2,3, Wanwan Liu 1,‡ for the Alzheimer’s Disease Neuroimaging Initiative, Zhijun Zhang 4,* and Qun Xu 1,2,3,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2024, 25(4), 2293; https://doi.org/10.3390/ijms25042293
Submission received: 10 January 2024 / Revised: 10 February 2024 / Accepted: 11 February 2024 / Published: 14 February 2024
(This article belongs to the Special Issue Vascular, Oxidative and Inflammatory Dysregulation in Neurodegenerative Diseases: Current Status and Future Therapeutic Perspectives)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The manuscript entitled “CD163 mediated small vessel injury in Alzheimer’s disease: An 2 exploration from neuroimaging to transcriptomic " by Chen et al., is potentially an important study, performed and connected finely. The authors have used various parameters to test their hypothesis. The following are some points that the authors should consider.

 

  1. The workflow chart in Figure 1 should be explained by the authors
  2. The authors double-check the statistical analysis in Figure 5(E), " The expression level of feature-selection genes".
  3. When comparing CD163 expression in Aβ treatment to control, did the authors check the percentage increased?
  4. In figure 7(G) Immunofluorescence staining, authors should double-check the merged image of Aβ-treated rat.

 

Thanks

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

Tha manuscript addresses a topic of interest, namely small vessel injury in MCI and early stage AD. Considering the improving knowledge on pathological early signatures of this disease would enhanced comprehension of the pathological mechanisms of MCI and positively impact patient stratification. Currently no effective drugs are available to treat AD, hence, outcomes of this ma work may also help identifying new molecular targets for drug discovery, in my opinion the manuscript own sufficient interest for publication on the IJMC.

The work is clearly presented as well as the main outcomes. English language is good. Minor mystypos can be easily revised.

Limitations of the work are critically presented and discussed. 

Comments on the Quality of English Language

The manuscript is clearly written. English style is fluent and just really few mistypos have been detected.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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