Tumor-Targeted Squaraine Dye for Near-Infrared Fluorescence-Guided Photodynamic Therapy
Abstract
:1. Introduction
2. Results
2.1. Optical Characterization and In Vitro ROS Assay
2.2. In Vitro Cytotoxicity and Intracellular ROS Generation
2.3. Time-Dependent In Vivo Tumor Retention and Photothermal Effect Test
2.4. In Vivo Photodynamic Therapeutic Efficacy
3. Discussion
4. Materials and Methods
4.1. Optical and Physicochemical Property Analyses
4.2. In Vitro Live-Cell Imaging
4.3. In Vitro Cytotoxicity Assay
4.4. In Vitro Cellular ROS Assay and Photodynamic Cytotoxicity
4.5. HT-29 Xenograft Mouse Model
4.6. In Vivo Time-Dependent Tumor Imaging
4.7. In Vivo Photodynamic Therapeutic Efficacy
4.8. Histological Analysis
4.9. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Park, Y.; Park, M.H.; Hyun, H. Tumor-Targeted Squaraine Dye for Near-Infrared Fluorescence-Guided Photodynamic Therapy. Int. J. Mol. Sci. 2024, 25, 3428. https://doi.org/10.3390/ijms25063428
Park Y, Park MH, Hyun H. Tumor-Targeted Squaraine Dye for Near-Infrared Fluorescence-Guided Photodynamic Therapy. International Journal of Molecular Sciences. 2024; 25(6):3428. https://doi.org/10.3390/ijms25063428
Chicago/Turabian StylePark, Yoonbin, Min Ho Park, and Hoon Hyun. 2024. "Tumor-Targeted Squaraine Dye for Near-Infrared Fluorescence-Guided Photodynamic Therapy" International Journal of Molecular Sciences 25, no. 6: 3428. https://doi.org/10.3390/ijms25063428