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Volume 25
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Communication

Dysfunction of Gpl1–Gih35–Wdr83 Complex in S. pombe Affects the Splicing of DNA Damage Repair Factors Resulting in Increased Sensitivity to DNA Damage

by
Ingrid Cipakova
1,*,
Matus Jurcik
1,
Tomas Selicky
1,
Laura Olivia Lalakova
1,
Jana Jakubikova
2 and
Lubos Cipak
1,*
1
Department of Genetics, Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia
2
Department of Tumor Immunology, Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(8), 4192; https://doi.org/10.3390/ijms25084192
Submission received: 7 March 2024 / Revised: 8 April 2024 / Accepted: 9 April 2024 / Published: 10 April 2024
(This article belongs to the Section Molecular Genetics and Genomics)
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Abstract

Pre-mRNA splicing plays a key role in the regulation of gene expression. Recent discoveries suggest that defects in pre-mRNA splicing, resulting from the dysfunction of certain splicing factors, can impact the expression of genes crucial for genome surveillance mechanisms, including those involved in cellular response to DNA damage. In this study, we analyzed how cells with a non-functional spliceosome-associated Gpl1–Gih35–Wdr83 complex respond to DNA damage. Additionally, we investigated the role of this complex in regulating the splicing of factors involved in DNA damage repair. Our findings reveal that the deletion of any component within the Gpl1–Gih35–Wdr83 complex leads to a significant accumulation of unspliced pre-mRNAs of DNA repair factors. Consequently, mutant cells lacking this complex exhibit increased sensitivity to DNA-damaging agents. These results highlight the importance of the Gpl1–Gih35–Wdr83 complex in regulating the expression of DNA repair factors, thereby protecting the stability of the genome following DNA damage.
Keywords: Gpl1; Gih35; Wdr83; G-patch protein; pre-mRNA splicing; DNA damage; S. pombe Gpl1; Gih35; Wdr83; G-patch protein; pre-mRNA splicing; DNA damage; S. pombe

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MDPI and ACS Style

Cipakova, I.; Jurcik, M.; Selicky, T.; Lalakova, L.O.; Jakubikova, J.; Cipak, L. Dysfunction of Gpl1–Gih35–Wdr83 Complex in S. pombe Affects the Splicing of DNA Damage Repair Factors Resulting in Increased Sensitivity to DNA Damage. Int. J. Mol. Sci. 2024, 25, 4192. https://doi.org/10.3390/ijms25084192

AMA Style

Cipakova I, Jurcik M, Selicky T, Lalakova LO, Jakubikova J, Cipak L. Dysfunction of Gpl1–Gih35–Wdr83 Complex in S. pombe Affects the Splicing of DNA Damage Repair Factors Resulting in Increased Sensitivity to DNA Damage. International Journal of Molecular Sciences. 2024; 25(8):4192. https://doi.org/10.3390/ijms25084192

Chicago/Turabian Style

Cipakova, Ingrid, Matus Jurcik, Tomas Selicky, Laura Olivia Lalakova, Jana Jakubikova, and Lubos Cipak. 2024. "Dysfunction of Gpl1–Gih35–Wdr83 Complex in S. pombe Affects the Splicing of DNA Damage Repair Factors Resulting in Increased Sensitivity to DNA Damage" International Journal of Molecular Sciences 25, no. 8: 4192. https://doi.org/10.3390/ijms25084192

APA Style

Cipakova, I., Jurcik, M., Selicky, T., Lalakova, L. O., Jakubikova, J., & Cipak, L. (2024). Dysfunction of Gpl1–Gih35–Wdr83 Complex in S. pombe Affects the Splicing of DNA Damage Repair Factors Resulting in Increased Sensitivity to DNA Damage. International Journal of Molecular Sciences, 25(8), 4192. https://doi.org/10.3390/ijms25084192

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