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Molbank
Volume 2021
Issue 2
10.3390/M1228
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Short Note

1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione

by
Vasiliki Pardali
,
Sotirios Katsamakas
,
Erofili Giannakopoulou
and
Grigoris Zoidis
*
Department of Pharmacy, Division of Pharmaceutical Chemistry, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
*
Author to whom correspondence should be addressed.
Molbank 2021, 2021(2), M1228; https://doi.org/10.3390/M1228
Submission received: 18 May 2021 / Revised: 25 May 2021 / Accepted: 1 June 2021 / Published: 4 June 2021
(This article belongs to the Special Issue Nitrogen-Containing Molecules: Natural and Synthetic Products Including Coordination Compounds)
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Abstract

A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields and no further purification. Therefore, the proposed method, with an overall yield of 60%, offers a facile pathway to the synthesis of N-1 monosubstituted spiro carbocyclic imidazolidine-2,4-diones (hydantoins), which constitute a privileged class of heterocyclic scaffolds with pharmacological interest.
Keywords: carbocyclic hydantoins; N-1 substituted hydantoin; spiro hydantoins; imidazolidine-2,4-diones; DFT calculations; stereochemistry; NMR; HRMS; GIAO; ring closing carbocyclic hydantoins; N-1 substituted hydantoin; spiro hydantoins; imidazolidine-2,4-diones; DFT calculations; stereochemistry; NMR; HRMS; GIAO; ring closing
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MDPI and ACS Style

Pardali, V.; Katsamakas, S.; Giannakopoulou, E.; Zoidis, G. 1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione. Molbank 2021, 2021, M1228. https://doi.org/10.3390/M1228

AMA Style

Pardali V, Katsamakas S, Giannakopoulou E, Zoidis G. 1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione. Molbank. 2021; 2021(2):M1228. https://doi.org/10.3390/M1228

Chicago/Turabian Style

Pardali, Vasiliki, Sotirios Katsamakas, Erofili Giannakopoulou, and Grigoris Zoidis. 2021. "1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione" Molbank 2021, no. 2: M1228. https://doi.org/10.3390/M1228

APA Style

Pardali, V., Katsamakas, S., Giannakopoulou, E., & Zoidis, G. (2021). 1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione. Molbank, 2021(2), M1228. https://doi.org/10.3390/M1228

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