5-Methyl-1-phenyl-3-(thieno[2,3-d]pyrimidin-4-yl)chromeno[4,3-d]pyrazolo[3,4-b]pyridin-6(3H)-one

Round 1

Reviewer 1 Report

“5-Methyl-1-phenyl-3-(thieno[2,3-d]pyrimidin-4-yl)chromeno[4,3-d]pyrazolo[3,4-b]pyridin-6(3H)-one”

The article describes the synthesis and characterization of a chromeno[4,3-d]pyrazolo[3,4-b]pyridinone derivative in high yield (75%), through the reaction between a thieno-pyrimidine derivative and 3-acetyl-2H-chromen-2-one.

Globally, the manuscript is well written and the introduction is adequate to the described compound. The experimental procedure is clear and the characterization data is in accordance with the synthesized compound.  

Author Response

Thank you for your kind reviewing this paper without any further corrections.

Reviewer 2 Report

The paper is publishable as the compound described is new. FeCl3 has been used (see ref 18) with 88% yield for preparing the same type of compound. An experience with FeCl3 itself could have been run to compare the result with the supported catalyst. The supported catalyst may have the advantage to facilitate the work-up.

Author Response

Thank you for your kind reviewing this paper with some suggestions.

In fact, we have studied synthetic reaction of 3 with a catalyst FeCl3 only or FeCl3-SiO2. Product yield using FeCl3-SiO2 are little better (69 : 75%). So we chose the supported catalyst for this reaction.

We changed and added in text as "The use of the heterogeneous catalyst for this reaction has advantages of low cost, easy work-up and enhanced yield, compared to FeCl3 alone (69% yield) or other catalysts [18]"