4,4′-Difluoro-[3,3′-bi(1,2,5-oxadiazole)] 2,2′-Dioxide
Round 1
Reviewer 1 Report
Please see attached review.
Comments for author File: 
Comments.pdf
Author Response
The authors are grateful to the reviewer for a kind and highly professional review.
Point 1.
The authors’ 19F chemical shift is reported as positive, as was common in older literature (Berger, Braun and Kalinowski, NMR Spectroscopy of the Non-Metallic Elements, p 398); these are upfield from CFCl3, so in modern times they are normally reported as negative numbers.
Response from authors.
Corrected as suggested by the reviewer.
Reviewer 2 Report
This manuscript describes an efficient synthesis of a difluoro-bisoxadiazole dioxide derivative 1. The target molecule was prepared from the corresponding bis-nitro derivative 2 by treatment with TBAF or CsF, efficiently. As mentioned by the authors, the product 1 would be a promising candidate for new drugs.
Chemistries described in this paper would be a nice piece of work and of interest for a number of researchers in this field.
I recommend this manuscript for publication in Molbank.
A minor points:
In the Introduction part, the authors mentioned that the importance of the molecule can generate NO which shows a variety of biological activities. However, the authors mentioned only the usefulness of the current reaction and product. The readers might confuse with this type of introduction and conclusion. These should point the same direction.
Author Response
The authors are grateful to the reviewer for a kind and highly professional review.
Point 1.
In the Introduction part, the authors mentioned that the importance of the molecule can generate NO which shows a variety of biological activities. However, the authors mentioned only the usefulness of the current reaction and product. The readers might confuse with this type of introduction and conclusion. These should point the same direction.
Response from authors.
Corrected as suggested by the reviewer.
Reviewer 3 Report
The authors proposed the reaction of 4,4'-dinitro-[3,3'-bi(1,2,5-oxadiazole)] 2,2'-dioxide with fluoro containing reagents (tetrabutylammonium fluoride or cesium fluoride) selectively gave bis-substitution product, 4,4'-difluoro-[3,3'-bi(1,2,5-oxadiazole)] 2,2'-dioxide. The structure of the synthesized compound was established by elemental analysis, 13C, 19F NMR and IR spectroscopy, and mass-spectrometry. For my opinion, the result is interesting which would be of interest to the broad readership of scientific community of organic chemistry. I support its publication in Molbank after addressing the following issues.
Author Response
The authors are grateful to the reviewer for a kind and highly professional review. The review did not mention any shortcomings that should have been corrected.
