8-Iodo-4-methyl-2-oxo-2H-chromen-7-yl Benzenesulfonate
Abstract
:1. Introduction
2. Results and Discussion
3. Conclusions
4. Materials and Methods
4.1. General Information
4.2. Synthesis of 7-Hydroxy-4-methyl-2H-chromen-2-one (1a)
4.3. Synthesis of 7-Hydroxy-8-iodo-4-methyl-2H-chromen-2-one (1b)
4.4. Synthesis of 4-Methyl-2-oxo-2H-chromen-7-yl Benzenesulfonate (3a)
4.5. Synthesis of 8-Iodo-4-methyl-2-oxo-2H-chromen-7-yl Benzenesulfonate (3b)
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Number | δH (Mult, J in Hz) | δC (ppm) | COSY | HMBC |
---|---|---|---|---|
Me | 2.39 (s) | 18.1 | -- | H–3 (3J) |
2 | -- | 159.2 | -- | H–3 (2J) |
3 | 6.41 (s) | 114.5 | -- | Me (3J) |
4 | -- | 152.6 | -- | Me (2J) |
4a | -- | 118.9 | -- | H–5 (2J) Me (3J) H–3 (3J) H–6 (3J) H–8 (3J) |
5 | 7.78 (d, J = 8.4) | 127.1 | H–6 (3J) | -- |
6 | 7.06 (dd, J = 8.6, 2.2) | 118.1 | H–5 (3J) | H–8 (3J) |
7 | -- | 150.6 | -- | H–6 (2J) H–8 (2J) H–5 (3J) |
8 | 7.12 (d, J = 2.4) | 110.3 | -- | H–6 (3J) |
8a | -- | 153.3 | -- | H–8 (2J) H–5 (3J) |
i | -- | 133.9 | -- | Hm (3J) |
o | 7.92 (dd, J = 8.4, 1.2) | 128.3 | Hm (3J) | Hm (2J) Hp (3J) |
m | 7.69 (dd, J = 8.0, 8.0) | 130.0 | Ho (3J) Hp (3J) | Ho (2J) |
p | 7.85 (tt, J = 7.4, 1.2) | 135.4 | Hm (3J) | Ho (3J) |
Number | δH (Mult, J in Hz) | δC (ppm) | COSY | HMBC |
---|---|---|---|---|
Me | 2.42 (s) | 18.2 | -- | H–3 (3J) |
2 | -- | 159.2 | -- | H–3 (2J) |
3 | 6.45 (s) | 114.8 | -- | Me (3J) |
4 | -- | 152.7 | -- | Me (2J) |
4a | -- | 119.1 | -- | Me (3J) H–3 (3J) H–6 (3J) |
5 | 7.84 (d, J = 8.8) | 126.8 | H–6 (3J) | -- |
6 | 7.16 (d, J = 8.8) | 117.9 | H–5 (3J) | -- |
7 | -- | 152.0 | -- | H–6 (2J) H–5 (3J) |
8 | -- | 84.0 | -- | H–6 (3J) |
8a | -- | 153.8 | -- | H–5 (3J) |
i | -- | 134.7 | -- | Hm (3J) |
o | 7.95 (d, J = 7.6) | 128.4 | Hm (3J) | Hm (2J) Hp (3J) |
m | 7.71 (dd, J = 7.8, 7.8) | 130.1 | Ho (3J) Hp (3J) | -- |
p | 7.88 (t, J = 7.4) | 135.6 | Hm (3J) | Ho (3J) |
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Pulido-Moreno, L.; Parra-Tibocha, A.; Ladino-Bejarano, A.; Macías, M.A.; Becerra, D.; Castillo, J.-C. 8-Iodo-4-methyl-2-oxo-2H-chromen-7-yl Benzenesulfonate. Molbank 2024, 2024, M1869. https://doi.org/10.3390/M1869
Pulido-Moreno L, Parra-Tibocha A, Ladino-Bejarano A, Macías MA, Becerra D, Castillo J-C. 8-Iodo-4-methyl-2-oxo-2H-chromen-7-yl Benzenesulfonate. Molbank. 2024; 2024(3):M1869. https://doi.org/10.3390/M1869
Chicago/Turabian StylePulido-Moreno, Luis, Andrés Parra-Tibocha, Alexander Ladino-Bejarano, Mario A. Macías, Diana Becerra, and Juan-Carlos Castillo. 2024. "8-Iodo-4-methyl-2-oxo-2H-chromen-7-yl Benzenesulfonate" Molbank 2024, no. 3: M1869. https://doi.org/10.3390/M1869