Genetic Contributions of Genes on Sex Chromosomes and Mitochondrial DNA in a Pedigreed Population
Round 1
Reviewer 1 Report
Authors developed novel methods for calculating the genetic contribution for genes on sex chromosomes and mitochondrial DNA by extending the method for calculating the genetic contribution of autosomal genes. To demonstrate the performance, we applied the methods for calculating genetic contributions to example pedigree data. Apply this method can assess the level of genetic diversity in livestock breeding. There are three questions: 1. Which allens were selected to apply in this method? 2).How to get the allens? and 3). This method is a good method to XY/XX, but how about to the ZZ/ZW?
But there are some comments as below:
In introduction: the part is better.
In method: the part is the important part in this manuscript. There are some information should be providing
L79: what is I and A? individual or generation? Individual I came from generation I? I suggest author add a figure to show individual and generation, and the F1 and so on.
L215: suggest add GCAI,A after genetic contributions.
Author Response
Please see the attachment.
Author Response File: 
Author Response.docx
Reviewer 2 Report
Title: Genetic contributions of genes on sex chromosomes and mitochondrial DNA in pedigreed population
Major comments.
The main concern in this study is that we have pedigree, autosomes, sex chromosomes, and mitochondrial DNA.
The genetic contribution could be estimated individually by the source of information. Even this, all these sources of information are presented in the same animal.
The question here is how we can decide which is the correct one? Or how we can weigh them in order to take into account all the sources of information. Table 3. Here one of each matrix could be used to mixed models equations, or as a kernel in Bayesian models.
In addition, which is the practical uses for all these sources of information in genetic conservation or animal breeding?
The source of information used to estimate the genetic contribution is related to specific traits. Example: maternal traits with mitochondrial DNA or spermatic traits with Y-chromosomes?
I encourage the authors to improve the explanations of the background, methodology and explanations of results and further applications of this valuable study.
Author Response
Please see the attachment.
Author Response File: Author Response.docx
Round 2
Reviewer 1 Report
this version is better. and there is no more question, I suggestted accept in present form.
Reviewer 2 Report
Please Accept in present form.
