Label-Free Biosensor Based on Particle Plasmon Resonance Coupled with Diffraction Grating Waveguide
Abstract
:1. Introduction
2. Materials and Methods
2.1. Reagents and Materials
2.2. Fabrication of Sensor Chips
2.3. Sensing System and Measurements
2.4. Preparation of AuNPs
2.5. Immobilization of AuNPs on Glass Slides
2.6. Functionalization of Gold Nanoparticle Surface
2.7. Preparation and Characterization of Photopolymerizable Sol–Gel Films
2.8. Fabrication of Grating
3. Results and Discussion
3.1. Characterization of Photopolymerizable Sol–Gel Films
3.2. Optimization of Incident Angle and PSD Position
3.3. Effect of Glass Slide Thickness on Sensitivity
3.4. Theoretical Simulations
3.5. Biosensing Tests
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Figure-of-Merit | Opposite-Side | Same-Side |
---|---|---|
SR (t = 1.0 mm) | 7.8 × 10−4 RIU | 8.3 × 10−4 RIU |
LOD for ant-DNP (t = 1.0 mm) | 5.8 × 10−11 M | 3.2 × 10−11 M |
LOD for ant-DNP (t = 0.05 mm) | 4.4 × 10−12 M | 1.4 × 10−12 M |
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Hsu, W.-T.; Lin, Y.-C.; Yang, H.-C.; Barshilia, D.; Chen, P.-L.; Huang, F.-C.; Chau, L.-K.; Hsieh, W.-H.; Chang, G.-E. Label-Free Biosensor Based on Particle Plasmon Resonance Coupled with Diffraction Grating Waveguide. Sensors 2024, 24, 5536. https://doi.org/10.3390/s24175536
Hsu W-T, Lin Y-C, Yang H-C, Barshilia D, Chen P-L, Huang F-C, Chau L-K, Hsieh W-H, Chang G-E. Label-Free Biosensor Based on Particle Plasmon Resonance Coupled with Diffraction Grating Waveguide. Sensors. 2024; 24(17):5536. https://doi.org/10.3390/s24175536
Chicago/Turabian StyleHsu, Wei-Ting, Yu-Cheng Lin, Huang-Chin Yang, Devesh Barshilia, Po-Liang Chen, Fu-Chun Huang, Lai-Kwan Chau, Wen-Hsin Hsieh, and Guo-En Chang. 2024. "Label-Free Biosensor Based on Particle Plasmon Resonance Coupled with Diffraction Grating Waveguide" Sensors 24, no. 17: 5536. https://doi.org/10.3390/s24175536