Radiosynthesis and Preclinical Evaluation of Bispecific PSMA/FAP Heterodimers for Tumor Imaging
Abstract
:1. Introduction
2. Results
2.1. Chemistry and Radiolabeling
2.2. Partition Coefficient and Stability
2.3. Cell Studies
2.4. Tissue Biodistribution Studies
2.5. Micro-PET Imaging
3. Discussion
4. Materials and Methods
4.1. Chemistry
4.2. Radiosynthesis
4.3. Partition Coefficient
4.4. In Vitro Serum Stability
4.5. In Vivo Stability
4.6. Cell Culture
4.7. In Vitro Cell Study
4.8. Tumor Xenotransplantation
4.9. Tissue Biodistribution Studies
4.10. Micro-PET Imaging
4.11. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Hu, K.; Li, L.; Huang, Y.; Ye, S.; Zhong, J.; Yan, Q.; Zhong, Y.; Fu, L.; Feng, P.; Li, H. Radiosynthesis and Preclinical Evaluation of Bispecific PSMA/FAP Heterodimers for Tumor Imaging. Pharmaceuticals 2022, 15, 383. https://doi.org/10.3390/ph15030383
Hu K, Li L, Huang Y, Ye S, Zhong J, Yan Q, Zhong Y, Fu L, Feng P, Li H. Radiosynthesis and Preclinical Evaluation of Bispecific PSMA/FAP Heterodimers for Tumor Imaging. Pharmaceuticals. 2022; 15(3):383. https://doi.org/10.3390/ph15030383
Chicago/Turabian StyleHu, Kongzhen, Li Li, Yong Huang, Shimin Ye, Jiawei Zhong, Qingsong Yan, Yuhua Zhong, Lilan Fu, Pengju Feng, and Hongsheng Li. 2022. "Radiosynthesis and Preclinical Evaluation of Bispecific PSMA/FAP Heterodimers for Tumor Imaging" Pharmaceuticals 15, no. 3: 383. https://doi.org/10.3390/ph15030383