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Volume 16
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Article

Horsetail (Equisetum hyemale) Extract Accelerates Wound Healing in Diabetic Rats by Modulating IL-10 and MCP-1 Release and Collagen Synthesis

by
Hilda Aguayo-Morales
,
Crystel A. Sierra-Rivera
,
Jesús A. Claudio-Rizo
* and
Luis E. Cobos-Puc
*
Facultad de Ciencias Químicas, Unidad Saltillo, Universidad Autónoma de Coahuila, Boulevard Venustiano Carranza S/N Esquina con Ing. José Cárdenas Valdés, República Oriente, Saltillo 25290, Mexico
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2023, 16(4), 514; https://doi.org/10.3390/ph16040514
Submission received: 25 January 2023 / Revised: 12 March 2023 / Accepted: 28 March 2023 / Published: 30 March 2023
(This article belongs to the Special Issue Ethnopharmacology in Latin America)
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Abstract

Traditionally, Equisetum hyemale has been used for wound healing. However, its mechanism of action remains to be elucidated. For this purpose, a 40% ethanolic extract of E. hyemale was prepared. Phytochemical screening revealed the presence of minerals, sterols, phenolic acids, flavonols, a lignan, and a phenylpropenoid. The extract reduced the viability of RAW 264.7 cells and skin fibroblasts at all times evaluated. On the third day of treatment, this reduction was 30–40% and 15–40%, respectively. In contrast, the extract increased the proliferation of skin fibroblasts only after 48 h. In addition, the extract increased IL-10 release and inhibited MCP-1 release. However, the extract did not affect both TGF-β1 and TNF-α released by RAW 264.7 cells. The higher release of IL-10 could be related to the up-/downregulation of inflammatory pathways mediated by the extract components associated with their bioactivity. The extract inhibited the growth of Staphylococcus aureus and Escherichia coli. Topical application of the extract accelerated wound healing in diabetic rats by increasing fibroblast collagen synthesis. These results suggest that E. hyemale extract has great potential for use in the treatment of wounds thanks to its phytochemical composition that modulates cytokine secretion, collagen synthesis, and bacterial growth.
Keywords: Equisetum hyemale; inflammation; cytokines; phenolic compounds; wound healing; type 2 diabetic rats Equisetum hyemale; inflammation; cytokines; phenolic compounds; wound healing; type 2 diabetic rats
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MDPI and ACS Style

Aguayo-Morales, H.; Sierra-Rivera, C.A.; Claudio-Rizo, J.A.; Cobos-Puc, L.E. Horsetail (Equisetum hyemale) Extract Accelerates Wound Healing in Diabetic Rats by Modulating IL-10 and MCP-1 Release and Collagen Synthesis. Pharmaceuticals 2023, 16, 514. https://doi.org/10.3390/ph16040514

AMA Style

Aguayo-Morales H, Sierra-Rivera CA, Claudio-Rizo JA, Cobos-Puc LE. Horsetail (Equisetum hyemale) Extract Accelerates Wound Healing in Diabetic Rats by Modulating IL-10 and MCP-1 Release and Collagen Synthesis. Pharmaceuticals. 2023; 16(4):514. https://doi.org/10.3390/ph16040514

Chicago/Turabian Style

Aguayo-Morales, Hilda, Crystel A. Sierra-Rivera, Jesús A. Claudio-Rizo, and Luis E. Cobos-Puc. 2023. "Horsetail (Equisetum hyemale) Extract Accelerates Wound Healing in Diabetic Rats by Modulating IL-10 and MCP-1 Release and Collagen Synthesis" Pharmaceuticals 16, no. 4: 514. https://doi.org/10.3390/ph16040514

APA Style

Aguayo-Morales, H., Sierra-Rivera, C. A., Claudio-Rizo, J. A., & Cobos-Puc, L. E. (2023). Horsetail (Equisetum hyemale) Extract Accelerates Wound Healing in Diabetic Rats by Modulating IL-10 and MCP-1 Release and Collagen Synthesis. Pharmaceuticals, 16(4), 514. https://doi.org/10.3390/ph16040514

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