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Article
Peer-Review Record

Unveiling the Potential of BenzylethyleneAryl–Urea Scaffolds for the Design of New Onco Immunomodulating Agents

Pharmaceuticals 2023, 16(6), 808; https://doi.org/10.3390/ph16060808
by Raquel Gil-Edo 1, Santiago Royo 2, Miguel Carda 1 and Eva Falomir 1,*
Reviewer 1:
Reviewer 2:
Pharmaceuticals 2023, 16(6), 808; https://doi.org/10.3390/ph16060808
Submission received: 24 April 2023 / Revised: 8 May 2023 / Accepted: 25 May 2023 / Published: 29 May 2023

Round 1

Reviewer 1 Report

The paper by Gil-Edo and coauthors describes the development of a series urea-based compounds as onco-immunomodulating agents. The the data are in general sound, so these compounds could be useful as lead compounds for further development.

My big concern is about the data in the Supporting Information:

1) Dose-response curves of the antiproliferative effects determined by MTT assay are completely missing;

2) 1H and 13C NMR have to be changed in 1H and 13C NMR

3) Integration of signals in the proton NMR are required, otherwise is difficult to check the spectrum

4) IR spectrum has extremely low quality, pickpicking is missing

5) HPLC chromatogram at least of the selected compounds is necessary for proving the purity of the molecules

 

Author Response

Please find answers in the attached file

Author Response File: Author Response.pdf

Reviewer 2 Report


Comments for author File: Comments.pdf

Minor English language correction required

Author Response

Please find answers in the attached file

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

Thank you for the answers and corrections

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