Urea and Thiourea Derivatives in Modern Drug Discovery and Medicinal Chemistry
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (10 May 2023) | Viewed by 5831
Special Issue Editor
Special Issue Information
Dear Colleagues,
Despite the continuous progress of medical science and the introduction of new drugs to the market, the effectiveness of the treatments for many diseases remains unsatisfactory. One of the major problems with drug therapy is the high variability in patients’ responses to the drug. Therefore, it is necessary to individualize treatment and to optimize the substances used in pharmacotherapy. The design, synthesis and commercialization of biologically active substances is a complex and long-term process. It requires the involvement and cooperation of scientists from various disciplines, including medicine, genetics, molecular biology, chemistry, materials science, and physics. Despite technological progress and the development of knowledge about the functioning of living organisms, the design of molecules with a specific profile of biological activity is still a challenge.
For several years, researchers have focused on urea and thiourea derivatives as pharmacophores for the search for new drugs. Chemical compounds containing urea or thiourea moieties in their structure show a broad range of biological activities thanks to certain interactions between proteins and receptor targets. Therefore, they are widely used in the search for new antimicrobial, anticancer, antituberculosis, antimalarial, antiviral or a-glucosidase inhibitor drug candidates.
In this Special Issue, we encourage you to submit articles on basic, preclinical and clinical research focusing on the design, synthesis and in vitro or in vivo biological research of new urea or thiourea compounds. Articles describing research into radiopharmaceuticals and drug delivery systems are valuable. Publications containing both original research and review articles as well as case studies are welcome.
Prof. Dr. Monika Pitucha
Guest Editor
Manuscript Submission Information
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Keywords
- urea
- thiourea
- antimicrobial
- anticancer
- pharmacology
- toxicology
- radioligands
- antioxidants
- pharmaceutical chemistry
- pharmaceutical analysis
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