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Roles of Sirtuins in Hearing Protection
by
Chail Koo
Chail Koo
Chail Koo is a postdoc at the Department of Otolaryngology, Northwestern University. He completed in [...]
Chail Koo is a postdoc at the Department of Otolaryngology, Northwestern University. He completed his PhD in Cancer Epigenetics at Imperial College London in 2023, after obtaining an MSc in Human Molecular Genetics at Imperial College London and BSc in Biochemistry at King's College London. He is currently investigating the roles of sirtuins and cisplatin-induced hearing loss.
1
,
Claus-Peter Richter
Claus-Peter Richter
Claus-Peter Richter is Vice Chair for Research in the Department of Otolaryngology, Head and Neck in [...]
Claus-Peter Richter is Vice Chair for Research in the Department of Otolaryngology, Head and Neck Surgery, and has joint appointments in the Department of Biomedical Engineering and the Department of Communication Sciences and Disorders, and is founding CTO of Resonance Medical, LLC. Prof. Richter received his medical degree from the Johann Wolfgang Goethe University in Frankfurt, Germany. Furthermore, he received his Master's in Physics and PhD from Johann Wolfgang Goethe-University. Following his postdoctoral research in the Department of Physiology at the Johann Wolfgang Goethe University, he joined the Laboratory of Dr. P. Dallos at Northwestern University in 1996 and became a full-time faculty member at Northwestern University Medical School in 2002. Prof. Richter's primary interests are the development and improvement of cochlear implant electrodes, the micromechanics of the mammalian cochlea, and the maturation of the mammalian inner ear.
1,2,3,4 and
Xiaodong Tan
Xiaodong Tan
Xiaodong Tan received his PhD in biomedical sciences from Creighton University in Nebraska and at of [...]
Xiaodong Tan received his PhD in biomedical sciences from Creighton University in Nebraska and completed postdoctoral research at the University of Wisconsin–Madison and Northwestern University, Illinois, where he is currently a assistant professor in the department of otolaryngology – head and neck surgery. Dr. Tan is an Editorial Board Member of Scientific Reports, Frontiers in Psychology, and Frontiers in Neuroscience. He is also an Associate Editor of Frontiers in Audiology and Otology. Dr. Tan has been marked by research in auditory function, hearing protection, and hearing restoration.
1,2,*
1
Department of Otolaryngology-Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
2
Hugh Knowles Center for Clinical and Basic Science in Hearing and Its Disorders, Northwestern University, Evanston, IL 60208, USA
3
Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
4
Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208, USA
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2024, 17(8), 998; https://doi.org/10.3390/ph17080998 (registering DOI)
Submission received: 28 June 2024
/
Revised: 20 July 2024
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Accepted: 26 July 2024
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Published: 28 July 2024
Abstract
Hearing loss is a health crisis that affects more than 60 million Americans. Currently, sodium thiosulfate is the only drug approved by the Food and Drug Administration (FDA) to counter hearing loss. Sirtuins were proposed as therapeutic targets in the search for new compounds or drugs to prevent or cure age-, noise-, or drug-induced hearing loss. Sirtuins are proteins involved in metabolic regulation with the potential to ameliorate sensorineural hearing loss. The mammalian sirtuin family includes seven members, SIRT1-7. This paper is a literature review on the sirtuins and their protective roles in sensorineural hearing loss. Literature search on the NCBI PubMed database and NUsearch included the keywords ‘sirtuin’ and ‘hearing’. Studies on sirtuins without relevance to hearing and studies on hearing without relevance to sirtuins were excluded. Only primary research articles with data on sirtuin expression and physiologic auditory tests were considered. The literature review identified 183 records on sirtuins and hearing. After removing duplicates, eighty-one records remained. After screening for eligibility criteria, there were forty-eight primary research articles with statistically significant data relevant to sirtuins and hearing. Overall, SIRT1 (n = 29) was the most studied sirtuin paralog. Over the last two decades, research on sirtuins and hearing has largely focused on age-, noise-, and drug-induced hearing loss. Past and current studies highlight the role of sirtuins as a mediator of redox homeostasis. However, more studies need to be conducted on the involvement of SIRT2 and SIRT4-7 in hearing protection.
Share and Cite
MDPI and ACS Style
Koo, C.; Richter, C.-P.; Tan, X.
Roles of Sirtuins in Hearing Protection. Pharmaceuticals 2024, 17, 998.
https://doi.org/10.3390/ph17080998
AMA Style
Koo C, Richter C-P, Tan X.
Roles of Sirtuins in Hearing Protection. Pharmaceuticals. 2024; 17(8):998.
https://doi.org/10.3390/ph17080998
Chicago/Turabian Style
Koo, Chail, Claus-Peter Richter, and Xiaodong Tan.
2024. "Roles of Sirtuins in Hearing Protection" Pharmaceuticals 17, no. 8: 998.
https://doi.org/10.3390/ph17080998
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