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Review

The Role of Ubiquitination in Regulation of Innate Immune Signaling

by
Ali Zohaib
1,2,†,
Xiaodong Duan
1,2,†,
Bibo Zhu
1,2,
Jing Ye
1,2,
Shengfeng Wan
1,2,
Huanchun Chen
1,2,
Xueqin Liu
3,* and
Shengbo Cao
1,2,*
1
State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, Hubei, China
2
Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, China
3
Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2016, 18(1), 1-10; https://doi.org/10.21775/cimb.018.001
Submission received: 13 January 2015 / Revised: 1 March 2015 / Accepted: 15 March 2015 / Published: 30 March 2015
Versions Notes

Abstract

Ubiquitination, also denoted ubiquitylation, is a posttranslational modification that has been implicated in the regulation of both innate and adaptive immune responses. Ubiquitination plays crucial roles in innate immune signaling by ensuring the proper orchestration of several signaling mediators that constitute a functional immune response. Herein, we briefly summarize the latest discoveries concerning the molecular ubiquitination-related machinery that senses, assembles, and disassembles innate immune signaling mediators.
Keywords: ubiquitination; ubiquitylation; posttranslational modification immune responses; immune signaling; signaling mediators ubiquitination; ubiquitylation; posttranslational modification immune responses; immune signaling; signaling mediators

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MDPI and ACS Style

Zohaib, A.; Duan, X.; Zhu, B.; Ye, J.; Wan, S.; Chen, H.; Liu, X.; Cao, S. The Role of Ubiquitination in Regulation of Innate Immune Signaling. Curr. Issues Mol. Biol. 2016, 18, 1-10. https://doi.org/10.21775/cimb.018.001

AMA Style

Zohaib A, Duan X, Zhu B, Ye J, Wan S, Chen H, Liu X, Cao S. The Role of Ubiquitination in Regulation of Innate Immune Signaling. Current Issues in Molecular Biology. 2016; 18(1):1-10. https://doi.org/10.21775/cimb.018.001

Chicago/Turabian Style

Zohaib, Ali, Xiaodong Duan, Bibo Zhu, Jing Ye, Shengfeng Wan, Huanchun Chen, Xueqin Liu, and Shengbo Cao. 2016. "The Role of Ubiquitination in Regulation of Innate Immune Signaling" Current Issues in Molecular Biology 18, no. 1: 1-10. https://doi.org/10.21775/cimb.018.001

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