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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

The Malaria Parasite's Achilles' Heel: Functionally-Relevant Invasion Structures

by
Manuel E. Patarroyo
1,2,*,
Martha P. Alba
1,3,
Cesar Reyes
1,
Rocio Rojas-Luna
1 and
Manuel A. Patarroyo
1,3
1
Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia
2
Universidad Nacional de Colombia, Bogotá, Colombia
3
Universidad del Rosario, Bogotá, Colombia
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2016, 18(1), 11-20; https://doi.org/10.21775/cimb.018.011
Submission received: 15 January 2015 / Revised: 2 March 2015 / Accepted: 15 March 2015 / Published: 1 April 2015
Versions Notes

Abstract

Malaria parasites have their Achilles' heel; they are vulnerable in small parts of their relevant molecules where they can be wounded and killed. These are sporozoite and merozoite protein conserved high activity binding peptides (cHABPs), playing a critical role in binding to and invasion of host cells (hepatocytes and erythrocytes, respectively). cHABPs can be modified by specific amino acid replacement, according to previously published physicochemical rules, to produce analogues (mHABPs) having left-handed polyproline II (PPIIL)-like structures which can modulate an immune response due to fitting perfectly into the HLA-DRβ1* peptide binding region (PBR) and having an appropriate presentation to the T-cell receptor (TCR).
Keywords: malaria; parasites; sporozoite; merozoite; protein conserved high activity binding peptides; cHABPs malaria; parasites; sporozoite; merozoite; protein conserved high activity binding peptides; cHABPs

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MDPI and ACS Style

Patarroyo, M.E.; Alba, M.P.; Reyes, C.; Rojas-Luna, R.; Patarroyo, M.A. The Malaria Parasite's Achilles' Heel: Functionally-Relevant Invasion Structures. Curr. Issues Mol. Biol. 2016, 18, 11-20. https://doi.org/10.21775/cimb.018.011

AMA Style

Patarroyo ME, Alba MP, Reyes C, Rojas-Luna R, Patarroyo MA. The Malaria Parasite's Achilles' Heel: Functionally-Relevant Invasion Structures. Current Issues in Molecular Biology. 2016; 18(1):11-20. https://doi.org/10.21775/cimb.018.011

Chicago/Turabian Style

Patarroyo, Manuel E., Martha P. Alba, Cesar Reyes, Rocio Rojas-Luna, and Manuel A. Patarroyo. 2016. "The Malaria Parasite's Achilles' Heel: Functionally-Relevant Invasion Structures" Current Issues in Molecular Biology 18, no. 1: 11-20. https://doi.org/10.21775/cimb.018.011

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