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Review

YBX1: A Multifunctional Protein in Senescence and Immune Regulation

by
Wenze Zhang
1,
Ying Liu
2,
Zhe Zhao
2,
Yizhi Zhang
2,
Yujuan Liang
2 and
Wanxia Wang
1,3,*
1
The First College of Clinical Medicine, Lanzhou University, Lanzhou 730000, China
2
The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
3
NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Lanzhou 730000, China
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2024, 46(12), 14058-14079; https://doi.org/10.3390/cimb46120841
Submission received: 18 November 2024 / Revised: 7 December 2024 / Accepted: 8 December 2024 / Published: 13 December 2024
(This article belongs to the Special Issue Protein Domains: Structure and Molecular Function)
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Abstract

The Y-box binding protein 1 (YBX1) is a multifunctional protein with a wide range of roles in cell biology. It plays a crucial role in immune modulation, senescence, and disease progression. This review presents a comprehensive analysis of the specific functions and mechanisms of YBX1 in these areas. Initially, YBX1 is shown to be closely associated with cellular senescence and impacts significant biological processes, including cell proliferation, damage repair, and metabolism. This suggests potential applications in the prevention and treatment of senescence-related diseases. Additionally, YBX1 regulates the immune response by controlling the function of immune cells and the expression of immune molecules. It is essential in maintaining immune system homeostasis and impacts the pathological process of various diseases, including tumors. Lastly, the diverse functions of the YBX1 protein make it a promising candidate for the development of innovative therapeutic strategies for diseases. Comprehensive research on its mechanisms could provide novel insights and approaches for the prevention, diagnosis, and treatment of related diseases.
Keywords: YBX1; cellular senescence; tumor immunity; immunotherapy YBX1; cellular senescence; tumor immunity; immunotherapy

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MDPI and ACS Style

Zhang, W.; Liu, Y.; Zhao, Z.; Zhang, Y.; Liang, Y.; Wang, W. YBX1: A Multifunctional Protein in Senescence and Immune Regulation. Curr. Issues Mol. Biol. 2024, 46, 14058-14079. https://doi.org/10.3390/cimb46120841

AMA Style

Zhang W, Liu Y, Zhao Z, Zhang Y, Liang Y, Wang W. YBX1: A Multifunctional Protein in Senescence and Immune Regulation. Current Issues in Molecular Biology. 2024; 46(12):14058-14079. https://doi.org/10.3390/cimb46120841

Chicago/Turabian Style

Zhang, Wenze, Ying Liu, Zhe Zhao, Yizhi Zhang, Yujuan Liang, and Wanxia Wang. 2024. "YBX1: A Multifunctional Protein in Senescence and Immune Regulation" Current Issues in Molecular Biology 46, no. 12: 14058-14079. https://doi.org/10.3390/cimb46120841

APA Style

Zhang, W., Liu, Y., Zhao, Z., Zhang, Y., Liang, Y., & Wang, W. (2024). YBX1: A Multifunctional Protein in Senescence and Immune Regulation. Current Issues in Molecular Biology, 46(12), 14058-14079. https://doi.org/10.3390/cimb46120841

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