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Volume 46
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10.3390/cimb46060317
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Review

Molecular Biological Research on the Pathogenic Mechanism of Retinoblastoma

by
Xiangyi Ma
†,
Xinyu Li
†,
Qi Sun
,
Fuxiao Luan
* and
Jing Feng
*
Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2024, 46(6), 5307-5321; https://doi.org/10.3390/cimb46060317
Submission received: 28 March 2024 / Revised: 14 May 2024 / Accepted: 20 May 2024 / Published: 27 May 2024
(This article belongs to the Collection Molecular Mechanisms in Human Diseases)
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Abstract

Retinoblastoma (RB) is the most common intraocular malignant tumor in children, primarily attributed to the bi-allelic loss of the RB1 gene in the developing retina. Despite significant progress in understanding the basic pathogenesis of RB, comprehensively unravelling the intricate network of genetics and epigenetics underlying RB tumorigenesis remains a major challenge. Conventional clinical treatment options are limited, and despite the continuous identification of genetic loci associated with cancer pathogenesis, the development of targeted therapies lags behind. This review focuses on the reported genomic and epigenomic alterations in retinoblastoma, summarizing potential therapeutic targets for RB and providing insights for research into targeted therapies.
Keywords: retinoblastoma; molecular biological; RB1; epigenetics retinoblastoma; molecular biological; RB1; epigenetics

Share and Cite

MDPI and ACS Style

Ma, X.; Li, X.; Sun, Q.; Luan, F.; Feng, J. Molecular Biological Research on the Pathogenic Mechanism of Retinoblastoma. Curr. Issues Mol. Biol. 2024, 46, 5307-5321. https://doi.org/10.3390/cimb46060317

AMA Style

Ma X, Li X, Sun Q, Luan F, Feng J. Molecular Biological Research on the Pathogenic Mechanism of Retinoblastoma. Current Issues in Molecular Biology. 2024; 46(6):5307-5321. https://doi.org/10.3390/cimb46060317

Chicago/Turabian Style

Ma, Xiangyi, Xinyu Li, Qi Sun, Fuxiao Luan, and Jing Feng. 2024. "Molecular Biological Research on the Pathogenic Mechanism of Retinoblastoma" Current Issues in Molecular Biology 46, no. 6: 5307-5321. https://doi.org/10.3390/cimb46060317

APA Style

Ma, X., Li, X., Sun, Q., Luan, F., & Feng, J. (2024). Molecular Biological Research on the Pathogenic Mechanism of Retinoblastoma. Current Issues in Molecular Biology, 46(6), 5307-5321. https://doi.org/10.3390/cimb46060317

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