Association between Maternal and Fetal Genetic Variants and Preeclampsia: Evidence from a Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy and Identification of Relevant Studies
2.2. Criteria for Inclusion and Exclusion
2.3. Data Extraction
2.4. Risk of Bias Assessment
2.5. Statistical Analysis
3. Results
3.1. Characterization of Eligible Studies
3.2. Association between Maternal Genetic Variants and Preeclampsia
3.3. Association between Fetal Genetic Variants and Preeclampsia
3.4. Association between Maternal and Fetal FLT1 Gene Regulatory Area rs4769613 Polymorphism and Preeclampsia
3.5. Association between Maternal and Fetal ACE rs4646994 Polymorphism and Preeclampsia
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gene ID | Variants | Ethic Group | Patient | Genotype Distribution | Allele Distribution | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PE | Normal | PE | Normal | PE | Normal | |||||||||
AA | Aa | aa | AA | Aa | aa | A | a | A | a | |||||
FLT1 | ||||||||||||||
Maternal | ||||||||||||||
McGinnis 2017 (1) M | rs4769613 | UK | 1875 | 5083 | 371 | 926 | 578 | 1152 | 2525 | 1396 | 1669 | 2081 | 4839 | 5327 |
McGinnis 2017 (2) M | rs4769613 | Norwegian | 1169 | 1927 | 270 | 584 | 315 | 444 | 962 | 521 | 1125 | 1213 | 1850 | 2004 |
McGinnis 2017 (3) M | rs4769613 | Finnish | 729 | 870 | 190 | 364 | 175 | 248 | 433 | 189 | 745 | 713 | 929 | 811 |
McGinnis 2017 (4) M | rs4769613 | Icelandic | 1205 | 135,190 | 236 | 595 | 374 | 29,737 | 67,335 | 38,118 | 1068 | 1342 | 126,808 | 143,572 |
Kikas 220 M | rs4769613 | Estonian | 18 | 135 | 3 | 9 | 6 | 39 | 80 | 16 | 15 | 21 | 158 | 112 |
Fetal | ||||||||||||||
McGinnis 2017 (1) F | rs4769613 | UK | 1004 | 5083 | 181 | 490 | 333 | 1152 | 2525 | 1396 | 851 | 1157 | 4839 | 5327 |
McGinnis 2017 (2) F | rs4769613 | Norwegian | 1125 | 1927 | 234 | 557 | 334 | 444 | 962 | 521 | 1026 | 1224 | 1850 | 2004 |
McGinnis 2017 (3) F | rs4769613 | Finnish | 527 | 870 | 112 | 262 | 153 | 248 | 433 | 189 | 487 | 567 | 929 | 811 |
McGinnis 2017 (4) F | rs4769613 | Icelandic | 411 | 135,190 | 77 | 202 | 132 | 29,737 | 67,335 | 38,118 | 356 | 466 | 126,808 | 143,572 |
Kikas 2020 F | rs4769613 | Estonian | 44 | 1724 | 9 | 22 | 13 | 535 | 870 | 319 | 40 | 48 | 1940 | 1508 |
ACE | ||||||||||||||
Maternal | ||||||||||||||
Morgan 1999 M | rs4646994 | White Caucasian | 72 | 83 | 18 | 31 | 23 | 22 | 36 | 25 | 67 | 77 | 80 | 86 |
Uma 2010 (1) M | rs4646994 | Caucasian - early PE | 22 | 105 | 2 | 8 | 12 | 22 | 61 | 22 | 12 | 32 | 105 | 105 |
Uma 2010 (2) M | rs4646994 | Caucasian - late PE | 38 | 105 | 12 | 19 | 7 | 22 | 61 | 22 | 43 | 33 | 105 | 105 |
Fetal | ||||||||||||||
Morgan 1999 F | rs4646994 | White Caucasian | 66 | 79 | 12 | 33 | 21 | 17 | 39 | 23 | 57 | 75 | 73 | 85 |
Uma 2010 (1) F | rs4646994 | Caucasian - early PE | 19 | 78 | 2 | 10 | 7 | 21 | 46 | 11 | 14 | 24 | 88 | 68 |
Uma 2010 (2) F | rs4646994 | Caucasian - late PE | 36 | 78 | 9 | 18 | 9 | 21 | 46 | 11 | 36 | 36 | 88 | 68 |
ERAP2 | ||||||||||||||
Maternal | ||||||||||||||
Hill 2011 (1) M | rs2549782 | Chilean | 528 | 575 | 57 | 233 | 238 | 69 | 261 | 245 | 347 | 709 | 399 | 751 |
Hill 2011 (2) M | rs2549782 | African American | 424 | 412 | 1 | 44 | 483 | 1 | 45 | 529 | 46 | 1010 | 47 | 1103 |
Hill 2011 (3) M | rs17408150 | Chilean | 528 | 575 | 78 | 208 | 138 | 63 | 196 | 153 | 364 | 484 | 322 | 502 |
Fetal | ||||||||||||||
Hill 2011 (1) F | rs2549782 | Chilean | 528 | 575 | 58 | 235 | 235 | 61 | 253 | 261 | 351 | 705 | 375 | 775 |
Hill 2011 (2) F | rs2549782 | African American | 375 | 462 | 1 | 40 | 487 | 1 | 43 | 531 | 42 | 1014 | 45 | 1105 |
Hill 2011 (3) F | rs17408150 | Chilean | 528 | 575 | 71 | 184 | 120 | 63 | 215 | 184 | 326 | 424 | 341 | 583 |
VEGF | ||||||||||||||
Maternal | ||||||||||||||
Procopciuc 2014 M | rs3025039 | Romanian | 47 | 94 | 20 | 23 | 0 | 70 | 21 | 3 | 63 | 23 | 161 | 27 |
Chen 2020 M | rs25648 | Han Chinese | 208 | 336 | 182 | 26 | 0 | 278 | 56 | 2 | 390 | 26 | 612 | 60 |
Chen 2020 M | rs3025000 | Han Chinese | 185 | 304 | 67 | 82 | 36 | 121 | 142 | 41 | 216 | 154 | 384 | 224 |
Chen 2020 M | rs2010963 | Han Chinese | 181 | 286 | 54 | 93 | 34 | 126 | 117 | 43 | 201 | 161 | 369 | 203 |
Fetal | ||||||||||||||
Procopciuc 2014 F | rs3025039 | Romanian | 47 | 94 | 19 | 23 | 5 | 63 | 28 | 3 | 61 | 33 | 154 | 34 |
Chen 2020 F | rs25648 | Han Chinese | 208 | 336 | 184 | 23 | 1 | 282 | 54 | 0 | 391 | 25 | 618 | 54 |
Chen 2020 F | rs3025000 | Han Chinese | 185 | 304 | 68 | 90 | 27 | 116 | 131 | 57 | 226 | 144 | 363 | 245 |
Chen 2020 F | rs2010963 | Han Chinese | 181 | 286 | 52 | 105 | 24 | 124 | 117 | 45 | 209 | 153 | 365 | 207 |
VDR | ||||||||||||||
Maternal | ||||||||||||||
Farajian 2020 M | rs2228570 | Iranian | 152 | 160 | 106 | 38 | 8 | 89 | 54 | 17 | 250 | 54 | 232 | 88 |
Farajian 2020 M | rs1544410 | Iranian | 152 | 160 | 39 | 86 | 27 | 40 | 90 | 30 | 164 | 140 | 170 | 150 |
Farajian 2020 M | rs731236 | Iranian | 152 | 160 | 59 | 71 | 22 | 65 | 70 | 25 | 189 | 115 | 200 | 120 |
Farajian 2020 M | rs7975232 | Iranian | 152 | 160 | 36 | 95 | 21 | 45 | 91 | 24 | 167 | 137 | 181 | 139 |
Fetal | ||||||||||||||
Farajian 2020 F | rs2228570 | Iranian | 106 | 121 | 76 | 22 | 8 | 69 | 36 | 16 | 174 | 38 | 174 | 68 |
Farajian 2020 F | rs1544410 | Iranian | 106 | 121 | 21 | 69 | 16 | 26 | 71 | 24 | 111 | 101 | 123 | 119 |
Farajian 2020 F | rs731236 | Iranian | 106 | 121 | 45 | 45 | 16 | 52 | 47 | 22 | 135 | 77 | 151 | 91 |
Farajian 2020 F | rs7975232 | Iranian | 106 | 121 | 29 | 53 | 24 | 32 | 68 | 21 | 111 | 101 | 132 | 110 |
REN | ||||||||||||||
Maternal | ||||||||||||||
Yu 2019 M | rs5705 | Han Chinese | 272 | 608 | 226 | 41 | 5 | 485 | 119 | 4 | 493 | 51 | 1089 | 127 |
Yu 2019 M | rs5707 | Han Chinese | 276 | 648 | 136 | 107 | 33 | 342 | 270 | 36 | 379 | 173 | 954 | 342 |
Yu 2019 M | rs2368564 | Han Chinese | 262 | 598 | 157 | 96 | 9 | 363 | 206 | 29 | 410 | 114 | 932 | 264 |
Fetal | ||||||||||||||
Yu 2019 F | rs5705 | Han Chinese | 272 | 608 | 225 | 42 | 5 | 490 | 111 | 7 | 492 | 52 | 1091 | 125 |
Yu 2019 F | rs5707 | Han Chinese | 276 | 648 | 140 | 96 | 40 | 333 | 270 | 45 | 376 | 176 | 936 | 360 |
Yu 2019 F | rs2368564 | Han Chinese | 262 | 598 | 156 | 93 | 13 | 365 | 208 | 25 | 405 | 119 | 938 | 258 |
MMP | ||||||||||||||
Maternal | ||||||||||||||
Sakowicz 2018 M | rs1799750 | Poland | 86 | 85 | 30 | 22 | 34 | 14 | 43 | 28 | 82 | 90 | 71 | 99 |
Sakowicz 2018 M | rs35068180 | Poland | 86 | 85 | 32 | 31 | 23 | 12 | 43 | 30 | 95 | 77 | 67 | 103 |
Sakowicz 2018 M | rs3918242 | Poland | 86 | 85 | 61 | 25 | 0 | 57 | 26 | 2 | 147 | 25 | 140 | 30 |
Sakowicz 2018 M | rs2285053 | Poland | 86 | 85 | 67 | 19 | 0 | 66 | 17 | 2 | 153 | 19 | 149 | 21 |
Sakowicz 2018 M | rs243865 | Poland | 86 | 85 | 52 | 30 | 4 | 49 | 30 | 6 | 134 | 38 | 128 | 42 |
Fetal | ||||||||||||||
Sakowicz 2018 F | rs1799750 | Poland | 86 | 85 | 30 | 43 | 13 | 12 | 36 | 37 | 103 | 69 | 60 | 110 |
Sakowicz 2018 F | rs35068180 | Poland | 86 | 85 | 12 | 62 | 12 | 17 | 41 | 27 | 86 | 86 | 75 | 95 |
Sakowicz 2018 F | rs3918242 | Poland | 86 | 85 | 67 | 19 | 0 | 61 | 21 | 3 | 153 | 19 | 143 | 27 |
Sakowicz 2018 F | rs2285053 | Poland | 86 | 85 | 66 | 18 | 2 | 69 | 15 | 1 | 150 | 22 | 153 | 17 |
Sakowicz 2018 F | rs243865 | Poland | 86 | 85 | 50 | 27 | 9 | 48 | 34 | 3 | 127 | 45 | 130 | 40 |
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Nguyen-Thanh, T.; Nguyen-Vu, P.-T.; Le-Thi, Q.-A.; Phan-Thi, T.-N.; Ha, T.-M.-T. Association between Maternal and Fetal Genetic Variants and Preeclampsia: Evidence from a Meta-Analysis. Curr. Issues Mol. Biol. 2024, 46, 8282-8300. https://doi.org/10.3390/cimb46080489
Nguyen-Thanh T, Nguyen-Vu P-T, Le-Thi Q-A, Phan-Thi T-N, Ha T-M-T. Association between Maternal and Fetal Genetic Variants and Preeclampsia: Evidence from a Meta-Analysis. Current Issues in Molecular Biology. 2024; 46(8):8282-8300. https://doi.org/10.3390/cimb46080489
Chicago/Turabian StyleNguyen-Thanh, Tung, Phuong-Thao Nguyen-Vu, Quy-Anh Le-Thi, Thao-Nguyen Phan-Thi, and Thi-Minh-Thi Ha. 2024. "Association between Maternal and Fetal Genetic Variants and Preeclampsia: Evidence from a Meta-Analysis" Current Issues in Molecular Biology 46, no. 8: 8282-8300. https://doi.org/10.3390/cimb46080489