Genetic Basis of Hypertrophic Cardiomyopathy in Cats
Abstract
:1. Introduction
2. Gene Mutations
2.1. MYBPC3 Protein Mutation
2.2. Myosin Heavy Chain Mutation
2.3. Alstrom’s Syndrom
2.4. Thin Filaments Mutations
2.5. Occurrence of Genetic Variants
MYBPC3:c.91 G > C [A31P] | Maine coon | [71] |
Pixiebob longhair | ||
Siberian | ||
No-breed | ||
Ragdoll | [32] | |
Munchkin | [72] | |
Scottish fold | ||
MYBPC3:c.2453 C > T [R818W] | American bobtail longhair | [32,71] |
American bobtail shorthair | ||
Highlander | ||
Munchkin | ||
RagaMuffin | ||
No-breed | ||
Ragdoll | ||
MYBPC3:c.220 G > A [A74T] | British shorthair | [32] |
British longhair | ||
Ragdoll | ||
Sphynx | ||
Maine coon | ||
Devon rex | ||
Norwegian forest cats | [68] | |
Persian | ||
Bengalskich | ||
Siberian | ||
Domestic shorthair | [27] | |
MYH7 c.5647 G > A [E1883K] | No-breed | [30] |
TNNT2:c.95-108 G > A | British shorthair | [32] |
British longhair | ||
Ragdoll | ||
Sphynx | ||
Maine coon | ||
Devon rex | ||
Maine coon | [66] | |
ALMS1:c.7384 G > C [G2462R] | Sphynx | [32] |
Devon rex | ||
Maine coon | ||
Ragdoll | ||
British short- or longhair | ||
Two cats with no known breed | [33] | |
American shorthair | [72] | |
Exotic shorthair | ||
Minuet | ||
Munchkin | ||
Scottish fold |
2.6. Effect of Homozygous and Heterozygous Mutation on HCM Phenotype
3. HCM-Related Gene Expression in Cats
4. Other Mechanisms Involved in the Development of HCM
5. Conclusions
Funding
Conflicts of Interest
References
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Grzeczka, A.; Graczyk, S.; Pasławski, R.; Pasławska, U. Genetic Basis of Hypertrophic Cardiomyopathy in Cats. Curr. Issues Mol. Biol. 2024, 46, 8752-8766. https://doi.org/10.3390/cimb46080517
Grzeczka A, Graczyk S, Pasławski R, Pasławska U. Genetic Basis of Hypertrophic Cardiomyopathy in Cats. Current Issues in Molecular Biology. 2024; 46(8):8752-8766. https://doi.org/10.3390/cimb46080517
Chicago/Turabian StyleGrzeczka, Arkadiusz, Szymon Graczyk, Robert Pasławski, and Urszula Pasławska. 2024. "Genetic Basis of Hypertrophic Cardiomyopathy in Cats" Current Issues in Molecular Biology 46, no. 8: 8752-8766. https://doi.org/10.3390/cimb46080517