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Communication

Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers

by
Maksym Zoziuk
1,
Vittorio Colizzi
2,
Pavlo Krysenko
3,
Maurizio Mattei
1,4,
Roberta Bernardini
5,
Fabio Massimo Zanzotto
6,
Stefano Marini
5 and
Dmitri Koroliouk
1,3,7,8,*
1
Centro Interdipartimentale di Medicina Comparata, Tecniche Alternative ed Acquacoltura, Interdepartmental Center for Comparative Medicine, Alternative Techniques, and Aquaculture, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
2
UNESCO Chair in Interdisciplinary Biotechnology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00173, Rome, Italy
3
Institute of Telecommunications and Global Information Space of the National Academy of Sciences of Ukraine, Chokolivskiy bulv. 13, 03186 Kyiv, Ukraine
4
Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00173 Rome, Italy
5
Faculty of Medicine, Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Roma, Italy
6
Department of Business Engineering “Mario Lucertini”, University of Rome Tor Vergata, Via del Politecnico, 1, 00133 Rome, Italy
7
Department of Microelectronics, Faculty of Electronics, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Beresteiska Ave. 37, 03056 Kyiv, Ukraine
8
Institute of Mathematics of the National Academy of Sciences of Ukraine, 3, Tereschenkivska St., 01004 Kyiv, Ukraine
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2025, 47(1), 42; https://doi.org/10.3390/cimb47010042
Submission received: 19 November 2024 / Revised: 3 January 2025 / Accepted: 7 January 2025 / Published: 9 January 2025
(This article belongs to the Special Issue The Significance of Transcription Factors, miRNAs, and lncRNAs in Anticancer Drug Development)
Review Reports Versions Notes

Abstract

Determining the relationships between miRNA expression, target genes, and cancer development is critical to cancer research. The possibility of correlating miRNA expression with plant or artificial ones provides prerequisites for cancer treatment. Based on the broad database of human miRNA expression for all cancer types, we grade human miRNAs by their expression level. The identified deficient miRNAs are compared with their target genes for coincidences in their expression directions. The replacement of human miRNAs is proposed to be implemented, using plant miRNAs closest to the human-deficient ones. Such plant substitutes are identified by analyzing the average complementarity of all human under-expressed miRNAs. It was established that the number of downregulated miRNAs is almost 2.5 times greater than that of upregulated miRNAs. There is no significant correlation between the expression of miRNA and genes, implying many other expression regulation mechanisms exist. Working on the organization of experimental verification of the obtained statistical studies, we present significant regularities that provide grounds for considering some plant microRNAs as possible means of compensating for insufficient expression of regulatory microRNAs in humans and animals in a wide range of oncological diseases.
Keywords: miRNA expression; cancer treatment; statistical complementarity; plant miRNAs miRNA expression; cancer treatment; statistical complementarity; plant miRNAs

Share and Cite

MDPI and ACS Style

Zoziuk, M.; Colizzi, V.; Krysenko, P.; Mattei, M.; Bernardini, R.; Zanzotto, F.M.; Marini, S.; Koroliouk, D. Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers. Curr. Issues Mol. Biol. 2025, 47, 42. https://doi.org/10.3390/cimb47010042

AMA Style

Zoziuk M, Colizzi V, Krysenko P, Mattei M, Bernardini R, Zanzotto FM, Marini S, Koroliouk D. Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers. Current Issues in Molecular Biology. 2025; 47(1):42. https://doi.org/10.3390/cimb47010042

Chicago/Turabian Style

Zoziuk, Maksym, Vittorio Colizzi, Pavlo Krysenko, Maurizio Mattei, Roberta Bernardini, Fabio Massimo Zanzotto, Stefano Marini, and Dmitri Koroliouk. 2025. "Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers" Current Issues in Molecular Biology 47, no. 1: 42. https://doi.org/10.3390/cimb47010042

APA Style

Zoziuk, M., Colizzi, V., Krysenko, P., Mattei, M., Bernardini, R., Zanzotto, F. M., Marini, S., & Koroliouk, D. (2025). Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers. Current Issues in Molecular Biology, 47(1), 42. https://doi.org/10.3390/cimb47010042

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