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Current Issues in Molecular Biology, Volume 47, Issue 1

January 2025 - 68 articles

Cover Story: This groundbreaking study introduces microbial-derived polydeoxyribonucleotide (L-PDRN) from Lactobacillus rhamnosus, a sustainable and enhanced alternative to the traditional salmon-derived PDRN. L-PDRN showcases superior antioxidant, wound-healing, and immunomodulatory properties. Its smaller DNA fragments (<100 bp) enable better bioavailability and skin absorption, setting new standards for regenerative and anti-inflammatory applications. This innovative approach not only addresses environmental and production challenges but also unlocks new therapeutic possibilities in oxidative stress management, tissue repair, and skincare. Pioneering a paradigm shift in PDRN sourcing, L-PDRN represents a versatile and eco-friendly biomaterial for future biomedical advancements. View this paper
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Articles (68)

  • Article
  • Open Access
1 Citations
2,995 Views
18 Pages

Hair loss is one of the skin conditions that can affect people’s mental health. Plant raw material extracts are of great interest due to their safety. In this study, we utilize reverse network pharmacology to screen for key targets of the Wnt/&...

  • Article
  • Open Access
1 Citations
1,910 Views
14 Pages

Targeting SLC4A4: A Novel Approach in Colorectal Cancer Drug Repurposing

  • Krunal Pawar,
  • Pramodkumar P. Gupta,
  • Pooran Singh Solanki,
  • Ravi Ranjan Kumar Niraj and
  • Shanker L. Kothari

Background: Colorectal cancer (CRC) is a complex and increasingly prevalent malignancy with significant challenges in its treatment and prognosis. This study aims to explore the role of the SLC4A4 transporter as a biomarker in CRC progression and its...

  • Case Report
  • Open Access
2 Citations
2,486 Views
7 Pages

Historically, EGFR and KRAS mutations were believed to be mutually exclusive. However, over the past few years, there have been emerging case reports showing the co-existence of both mutations in a single case. The majority of these co-occurring alte...

  • Review
  • Open Access
2 Citations
3,728 Views
16 Pages

Impact of Thrombopoietin Receptor Agonists on Pathophysiology of Pediatric Immune Thrombocytopenia

  • Paschalis Evangelidis,
  • Konstantinos Tragiannidis,
  • Eleni Gavriilaki and
  • Athanasios Tragiannidis

Immune thrombocytopenia (ITP) in pediatric patients is a common cause of isolated thrombocytopenia. Various pathophysiological mechanisms are implicated in ITP pathogenesis, including the production of autoantibodies against components of platelets (...

  • Communication
  • Open Access
2 Citations
1,481 Views
6 Pages

The First Complete Chloroplast Genome Sequence of Secale strictum subsp. africanum Stapf (Poaceae), the Putative Ancestor of the Genus Secale

  • Lidia Skuza,
  • Piotr Androsiuk,
  • Romain Gastineau,
  • Magdalena Achrem,
  • Łukasz Paukszto and
  • Jan Paweł Jastrzębski

Secale strictum ssp. africanum (synonym Secale africanum), a putative ancestor of the genus Secale, has been classified within Secale strictum, although recent phylogenetic studies suggest that it represents a distinct species. This study reports the...

  • Review
  • Open Access
2 Citations
2,182 Views
15 Pages

Metabolite-Sensing Receptors: Emerging Targets for Modulating Chronic Pain Pathways

  • Ciprian Pușcașu,
  • Corina Andrei,
  • Octavian Tudorel Olaru and
  • Anca Zanfirescu

Chronic pain is a debilitating condition affecting millions worldwide, often resulting from complex interactions between the nervous and immune systems. Recent advances highlight the critical role of metabolite-sensing G protein-coupled receptors (GP...

  • Communication
  • Open Access
2 Citations
1,698 Views
10 Pages

The development of accurate and high-throughput tools for cancer biomarker detection is crucial for the diagnosis, monitoring, and treatment of diseases. In this study, we developed a simple and rapid fluorescence-linked immunosorbent assay (FLISA) u...

  • Review
  • Open Access
2,401 Views
13 Pages

Sensory processing abnormalities have been noted since the first clinical description of autism in 1940. However, it was not until the release of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in 2013 that sens...

  • Review
  • Open Access
5 Citations
13,460 Views
19 Pages

Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker

  • Katarzyna Szymulewska-Konopko,
  • Joanna Reszeć-Giełażyn and
  • Monika Małeczek

Ferritin is found in all cells of the body, serving as a reservoir of iron and protecting against damage to the molecules that make up cellular structures. It has emerged as a biomarker not only for iron-related disorders but also for inflammatory di...

  • Article
  • Open Access
1 Citations
1,568 Views
13 Pages

Understanding the ammonium (NH4+) uptake and transport systems, particularly AMT1 genes, is important for plant growth and defense. However, there is a lack of research on identifying and analyzing AMT1 genes in pomegranate, emphasizing the need for...

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Curr. Issues Mol. Biol. - ISSN 1467-3045Creative Common CC BY license