Cisplatin increases urinary sodium excretion in rats: gender-related differences
Abstract
Materials and methods. Twelve control Wistar rats (6 males and 6 females) and 12 cisplatintreated Wistar rats (6 males and 6 females) after a single and repeated injection of cisplatin (once a day for 3 days) at a dose of 2.5 mg/kg body weight into the caudal vein were examined. The experiment was carried out by measuring 24-h urinary sodium, potassium, chloride, magnesium, creatinine excretion and pH in the urine of age-matched male and female rats.
Results. The 24-h urinary sodium excretion, sodium/chloride ratio, and diuresis showed no gender-related differences in control rats. After a single administration of 2.5 mg/kg cisplatin, 24-h urinary sodium excretion was not significantly higher in cisplatin-treated rats than in gender-matched controls. After repeated cisplatin administration, 24-h urinary sodium excretion was significantly higher in cisplatin-treated male rats as compared to matched controls (P<0.05). No such effect was found in cisplatin-treated female rats.
Conclusion. The study data show that cisplatin enhances urinary sodium excretion in male but not in female rats. The mechanism of such a gender-related effect is not yet clear. Further investigations are necessary to elucidate the mechanism of this pharmacological effect of cisplatin.
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Stakišaitis, D.; Dudėnienė, G.; Jankūnas, R.J.; Graželienė, G.; Didžiapetrienė, J.; Pundzienė, B. Cisplatin increases urinary sodium excretion in rats: gender-related differences. Medicina 2010, 46, 45. https://doi.org/10.3390/medicina46010008
Stakišaitis D, Dudėnienė G, Jankūnas RJ, Graželienė G, Didžiapetrienė J, Pundzienė B. Cisplatin increases urinary sodium excretion in rats: gender-related differences. Medicina. 2010; 46(1):45. https://doi.org/10.3390/medicina46010008
Chicago/Turabian StyleStakišaitis, Donatas, Giedrė Dudėnienė, Rimas Jonas Jankūnas, Gražina Graželienė, Janina Didžiapetrienė, and Birutė Pundzienė. 2010. "Cisplatin increases urinary sodium excretion in rats: gender-related differences" Medicina 46, no. 1: 45. https://doi.org/10.3390/medicina46010008