HLA class II alleles and haplotypes in Lithuanian children with type 1 diabetes and healthy children (HLA and type 1 diabetes)
Abstract
Material and methods. In this case-control study, 124 children with diabetes (55 males and 69 females; mean age, 9.2±3.9 years) were tested for HLA class II and compared with 78 healthy controls (43 males and 35 females; mean age, 10.8±3.4 years; range, 0–15 years). HLA DRB1, DQA1, and DQB1 alleles were genotyped using a polymerase chain reaction.
Results. T1D risk-associated haplotypes (DR4)-DQA1*0301-DQB1*0302, (DR3)- DQA1*0501-DQB1*0201, and (DR1)-DQA1*0101-04-DQB1*0501 were more prevalent among children with diabetes than controls (50.0%, 41.1%, and 37.9% vs. 10.3%, 5.1%, and 24.4%, P<0.001). The haplotypes (DR4)-DQA1*0301-DQB1*0302 and (DR3)-DQA1*0501-DQB1*0201 increased T1D risk by 8.75 and 12.93 times, respectively (P<0.001). Protective haplotypes (DR2)- DQA1*0102-B1*0602, (DR11/12/13)-DQA1*05-DQB1*0301, and (DR13)-DQA1*0103- DQB1*0603 were significantly more prevalent among controls than children with diabetes (25.6%, 33.3%, 19.2% vs. 0%, 3.2%, 0%; P<0.001). These frequencies are quite similar to those from neighbor countries with varying incidence of type 1 diabetes mellitus.
Conclusions. HLA class II haplotypes associated with type 1 diabetes mellitus positively or negatively were the same in Lithuanian children as in other European Caucasian populations. Differences in incidence and clinical manifestations of type 1 diabetes might be due to different environmental factors and/or lifestyle.
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Skrodenienė, E.; Marčiulionytė, D.; Padaiga, Ž.; Jašinskienė, E.; Sadauskaitė-Kuehne, V.; Sanjeevi, C.B.; Ludvigsson, J. HLA class II alleles and haplotypes in Lithuanian children with type 1 diabetes and healthy children (HLA and type 1 diabetes). Medicina 2010, 46, 505. https://doi.org/10.3390/medicina46080072
Skrodenienė E, Marčiulionytė D, Padaiga Ž, Jašinskienė E, Sadauskaitė-Kuehne V, Sanjeevi CB, Ludvigsson J. HLA class II alleles and haplotypes in Lithuanian children with type 1 diabetes and healthy children (HLA and type 1 diabetes). Medicina. 2010; 46(8):505. https://doi.org/10.3390/medicina46080072
Chicago/Turabian StyleSkrodenienė, Erika, Dalia Marčiulionytė, Žilvinas Padaiga, Edita Jašinskienė, Vaiva Sadauskaitė-Kuehne, Carani B. Sanjeevi, and Johnny Ludvigsson. 2010. "HLA class II alleles and haplotypes in Lithuanian children with type 1 diabetes and healthy children (HLA and type 1 diabetes)" Medicina 46, no. 8: 505. https://doi.org/10.3390/medicina46080072