Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis: A Prospective Study
Abstract
Material and Methods. The Hull airway reflux questionnaire (HARQ) was completed by 40 patients with IPF and 50 controls in order to evaluate reflux symptoms. EBC was collected from 23 patients (17 patients with IPF and 6 controls) for measurement of pepsin by the lateral flow technique. A prospective study of 57 subjects (34 patients with IPF and 23 controls) for H. pylori antibody detection by ELISA was performed.
Results. Significantly higher HARQ scores (maximum score, 70) were recorded in patients with IPF compared with controls (19.6 [SD, 12.4] vs. 3 [SD, 2.9], P<0.001). There was no significant difference in EBC pepsin positivity between patients with IPF and controls (2 of the 17 patients vs. none of the 6 controls, P=0.38). There was no significant difference in H. pylori serology between patients with IPF and controls (17 of the 34 patients vs. 14 of the 23 controls, P=0.42).
Conclusion. Patients with IPF had significantly increased scores of airway reflux symptoms. However, no objective evidence of extraesophageal reflux or H. pylori infection in patients with IPF was obtained in this study. The role of gastroesophageal and extraesophageal reflux in pathogenesis of IPF should be evaluated in a larger prospective study.
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Fahim, A.; Dettmar, P.W.; Morice, A.H.; Hart, S.P. Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis: A Prospective Study. Medicina 2011, 47, 28. https://doi.org/10.3390/medicina47040028
Fahim A, Dettmar PW, Morice AH, Hart SP. Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis: A Prospective Study. Medicina. 2011; 47(4):28. https://doi.org/10.3390/medicina47040028
Chicago/Turabian StyleFahim, Ahmed, Peter W. Dettmar, Alyn H. Morice, and Simon P. Hart. 2011. "Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis: A Prospective Study" Medicina 47, no. 4: 28. https://doi.org/10.3390/medicina47040028