Prevalence of dyslipidemia in statin-treated patients in the Baltic states (Estonia, Latvia, and Lithuania): Results of the Dyslipidemia International Study (DYSIS)
Abstract
Material and methods: Patients in primary care centers across the Baltic nations were enrolled into the cross-sectional, observational Dyslipidemia International Study (DYSIS). Patients were ≥45 years old and had been treated with statins for at least three months. Patient characteristics and lipid measurements were used to determine variables contributing to dyslipidemia (abnormal low-density lipoprotein cholesterol [LDL-C], high-density lipopro- tein cholesterol [HDL-C], or total triglyceride [TG] values).
Results: We enrolled 1797 patients with a mean age of 66.1 years and 59.1% being female. Overall 63.4% had cardiovascular disease, 30.1% were diabetic and 77.8% at high risk for cardiovascular complications. LDL-C was not at target level for 80.7%; low HDL-C levels were observed for 26.0%, and elevated TG levels were found in 35.0% of all patients. Multivariate analyses indicated that a BMI ≥ 30 kg/m2 (OR, 2.12; 95% CI, 1.45–3.08) and hypertension (OR, 2.43; 95% CI, 1.1 6–5.10) were strongly associated with dyslipidemia (involving all three lipids) during statin therapy while age ≥70 years (OR, 0.63; 95% CI, 0.42–0.94) and female gender (OR, 0.48; 95% CI, 0.33–0.68) conferred reduced risk.
Conclusions: Our findings indicate many statin-treated patients in Estonia, Latvia, and Lithuania did not meet target lipid levels and had a very high risk of CVD. Combating other well-known CVD risk factors such as obesity and hypertension is vital to reduce the exceptionally high riskfor CVD mortality seen in the Baltic nations.
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Viigimaa, M.; Erglis, A.; Latkovskis, G.; Mäeots, E.; Petrulionienė, Ž.; Šlapikas, R.; Gocentiene, A.; Bramlage, P.; Brudi, P. Prevalence of dyslipidemia in statin-treated patients in the Baltic states (Estonia, Latvia, and Lithuania): Results of the Dyslipidemia International Study (DYSIS). Medicina 2014, 50, 44-53. https://doi.org/10.1016/j.medici.2014.05.003
Viigimaa M, Erglis A, Latkovskis G, Mäeots E, Petrulionienė Ž, Šlapikas R, Gocentiene A, Bramlage P, Brudi P. Prevalence of dyslipidemia in statin-treated patients in the Baltic states (Estonia, Latvia, and Lithuania): Results of the Dyslipidemia International Study (DYSIS). Medicina. 2014; 50(1):44-53. https://doi.org/10.1016/j.medici.2014.05.003
Chicago/Turabian StyleViigimaa, Margus, Andrejs Erglis, Gustavs Latkovskis, Ene Mäeots, Žaneta Petrulionienė, Rimvydas Šlapikas, Anete Gocentiene, Peter Bramlage, and Philippe Brudi. 2014. "Prevalence of dyslipidemia in statin-treated patients in the Baltic states (Estonia, Latvia, and Lithuania): Results of the Dyslipidemia International Study (DYSIS)" Medicina 50, no. 1: 44-53. https://doi.org/10.1016/j.medici.2014.05.003